A8AXZ6 · AROD_STRGC

Function

function

Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.

Catalytic activity

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7.

Features

Showing features for binding site, active site.

122520406080100120140160180200220
TypeIDPosition(s)Description
Binding site63-dehydroquinate (UniProtKB | ChEBI)
Binding site30-323-dehydroquinate (UniProtKB | ChEBI)
Binding site623-dehydroquinate (UniProtKB | ChEBI)
Active site118Proton donor/acceptor
Active site143Schiff-base intermediate with substrate
Binding site1863-dehydroquinate (UniProtKB | ChEBI)
Binding site2053-dehydroquinate (UniProtKB | ChEBI)
Binding site2093-dehydroquinate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Function3-dehydroquinate dehydratase activity
Biological Process3,4-dihydroxybenzoate biosynthetic process
Biological Processamino acid biosynthetic process
Biological Processaromatic amino acid family biosynthetic process
Biological Processchorismate biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    3-dehydroquinate dehydratase
  • EC number
  • Short names
    3-dehydroquinase
  • Alternative names
    • Type I DHQase
    • Type I dehydroquinase
      (DHQ1
      )

Gene names

    • Name
      aroD
    • Ordered locus names
      SGO_1375

Organism names

Accessions

  • Primary accession
    A8AXZ6

Proteomes

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10000780511-2253-dehydroquinate dehydratase

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the type-I 3-dehydroquinase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    225
  • Mass (Da)
    25,730
  • Last updated
    2007-10-23 v1
  • Checksum
    4370521B912359A8
MKLVVSVTPRNLEEAQQIDAQRFVDADLIEWRADFLEKEEILKVAPAIFEKFAGRELIFTLRTKDEGGHIQLSDDEYVEMIKKVAQLYQPDYVDFEYFSHKDKIDEMLEFPNLVLSYHNFEETPENMMEILSELTSLTPKAVKVSVMANSGQDVLDLMNYTRGFKTLNPEQEYVTISMGRVGRISRIASDLTGSSWSFASLDEATAPGQISLSSMKKIRDILNEN

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000725
EMBL· GenBank· DDBJ
ABV10967.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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