A7ZTG2 · GPDA_ECO24

Function

function

Catalyzes the reduction of the glycolytic intermediate dihydroxyacetone phosphate (DHAP) to sn-glycerol 3-phosphate (G3P), the key precursor for phospholipid synthesis.

Catalytic activity

Pathway

Membrane lipid metabolism; glycerophospholipid metabolism.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site15NADPH (UniProtKB | ChEBI)
Binding site16NADPH (UniProtKB | ChEBI)
Binding site36NADPH (UniProtKB | ChEBI)
Binding site110NADPH (UniProtKB | ChEBI)
Binding site110sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site139sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site141sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site143NADPH (UniProtKB | ChEBI)
Active site195Proton acceptor
Binding site195sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site248sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site258sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site259NADPH (UniProtKB | ChEBI)
Binding site259sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site260sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site283NADPH (UniProtKB | ChEBI)
Binding site285NADPH (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionglycerol-3-phosphate dehydrogenase (NADP+) activity
Molecular Functionglycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Molecular FunctionNAD binding
Biological Processcarbohydrate metabolic process
Biological Processglycerol-3-phosphate biosynthetic process
Biological Processglycerol-3-phosphate catabolic process
Biological Processglycerophospholipid biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Glycerol-3-phosphate dehydrogenase [NAD(P)+]
  • EC number
  • Alternative names
    • NAD(P)(+)-dependent glycerol-3-phosphate dehydrogenase
    • NAD(P)H-dependent dihydroxyacetone-phosphate reductase

Gene names

    • Name
      gpsA
    • Ordered locus names
      EcE24377A_4112

Organism names

Accessions

  • Primary accession
    A7ZTG2

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10000607821-339Glycerol-3-phosphate dehydrogenase [NAD(P)+]

Structure

Family & Domains

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    339
  • Mass (Da)
    36,362
  • Last updated
    2007-10-23 v1
  • Checksum
    DF95F674204276BE
MNQRNASMTVIGAGSYGTALAITLARNGHEVVLWGHDPEHIATLERDRCNAAFLPDVPFPDTLHLESDLATALAASRNILVVVPSHVFGEVLRQIKPLMRPDARLVWATKGLEAETGRLLQDVAREALGDQIPLAVISGPTFAKELAAGLPTAISLASTDQTFADDLQQLLHCGKSFRVYSNPDFIGVQLGGAVKNVIAIGAGMSDGIGFGANARTALITRGLAEMSRLGAALGADPATFMGMAGLGDLVLTCTDNQSRNRRFGMMLGQGMDVQSAQEKIGQVVEGYRNTKEVRELAHRFGVEMPITEEIYQVLYCGKNAREAALTLLGRARKDERSSH

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000800
EMBL· GenBank· DDBJ
ABV18160.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp