A6VID5 · HPRT_METM7
- ProteinHypoxanthine/guanine phosphoribosyltransferase
- Genehpt
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids185 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis.
Catalytic activity
- IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate
Pathway
Purine metabolism; IMP biosynthesis via salvage pathway; IMP from hypoxanthine: step 1/1.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | guanine phosphoribosyltransferase activity | |
Molecular Function | hypoxanthine phosphoribosyltransferase activity | |
Biological Process | IMP salvage | |
Biological Process | purine ribonucleoside salvage |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameHypoxanthine/guanine phosphoribosyltransferase
- EC number
- Short namesHGPRTase
Gene names
Organism names
- Strain
- Taxonomic lineageArchaea > Euryarchaeota > Methanomada group > Methanococci > Methanococcales > Methanococcaceae > Methanococcus
Accessions
- Primary accessionA6VID5
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000329375 | 1-185 | Hypoxanthine/guanine phosphoribosyltransferase | |||
Sequence: MSRLLEESLKTCPIVKRGEYHYFIHPISDGVPLVKPELLRDVSTRVIKMIDTDIDKIVTAEAMGIPIVTAVSIATDIPYVIMRKREYLLEGEIPVHQETGYSKGELYLNGINKGDKVVILDDVISTGGTLVAIINALKRAGADIKDVLCIIDRGNGQNVVEEKTGYKVKTLVKIEVVDGKVQILE |
Interaction
Structure
Sequence
- Sequence statusComplete
- Length185
- Mass (Da)20,429
- Last updated2007-08-21 v1
- Checksum19665ACE7685686C
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP000745 EMBL· GenBank· DDBJ | ABR66211.1 EMBL· GenBank· DDBJ | Genomic DNA |