A6UWM1 · PIMT_META3
- ProteinProtein-L-isoaspartate O-methyltransferase
- Genepcm
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids216 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.
Catalytic activity
- [protein]-L-isoaspartate + S-adenosyl-L-methionine = [protein]-L-isoaspartate alpha-methyl ester + S-adenosyl-L-homocysteine
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 60 | |||||
Sequence: S |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | protein-L-isoaspartate (D-aspartate) O-methyltransferase activity | |
Biological Process | methylation | |
Biological Process | protein modification process | |
Biological Process | protein repair |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameProtein-L-isoaspartate O-methyltransferase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageArchaea > Euryarchaeota > Methanomada group > Methanococci > Methanococcales > Methanococcaceae > Methanococcus
Accessions
- Primary accessionA6UWM1
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_1000004820 | 1-216 | Protein-L-isoaspartate O-methyltransferase | |||
Sequence: MTIKKMEAIVKGLINAGYLKNKMVSKALLTVPRHEFIPAELHDYAYVDTPLNIGHGQTISAIHMVAIICDALDLKEGDKVLEIGTGSGYHAAVVAEIVGKNGQVITIERIPELAEKAESTLKKLGYTNVKVICGNGTLGSSEFAPYDKIYLTASGPDIPNSLIEQLKKGGKLVAPVGLYIQDLILLEKKNGNIIKKNLGAVAFVPLIGKNGWHNEY |
Interaction
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length216
- Mass (Da)23,318
- Last updated2007-08-21 v1
- ChecksumA182A302804A06C7
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP000743 EMBL· GenBank· DDBJ | ABR56893.1 EMBL· GenBank· DDBJ | Genomic DNA |