A6TGK9 · METE_KLEP7

Function

function

Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Pathway

Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetE route): step 1/1.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site17-205-methyltetrahydropteroyltri-L-glutamate (UniProtKB | ChEBI)
Binding site1175-methyltetrahydropteroyltri-L-glutamate (UniProtKB | ChEBI)
Binding site431-433L-homocysteine (UniProtKB | ChEBI)
Binding site431-433L-methionine (UniProtKB | ChEBI)
Binding site484L-homocysteine (UniProtKB | ChEBI)
Binding site484L-methionine (UniProtKB | ChEBI)
Binding site515-5165-methyltetrahydropteroyltri-L-glutamate (UniProtKB | ChEBI)
Binding site5615-methyltetrahydropteroyltri-L-glutamate (UniProtKB | ChEBI)
Binding site599L-homocysteine (UniProtKB | ChEBI)
Binding site599L-methionine (UniProtKB | ChEBI)
Binding site6055-methyltetrahydropteroyltri-L-glutamate (UniProtKB | ChEBI)
Binding site641Zn2+ (UniProtKB | ChEBI); catalytic
Binding site643Zn2+ (UniProtKB | ChEBI); catalytic
Binding site665Zn2+ (UniProtKB | ChEBI); catalytic
Active site694Proton donor
Binding site726Zn2+ (UniProtKB | ChEBI); catalytic

GO annotations

AspectTerm
Molecular Function5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity
Molecular Functionzinc ion binding
Biological Processmethionine biosynthetic process
Biological Processmethylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase
  • EC number
  • Alternative names
    • Cobalamin-independent methionine synthase
    • Methionine synthase, vitamin-B12 independent isozyme

Gene names

    • Name
      metE
    • ORF names
      KPN_04325
    • Ordered locus names
      KPN78578_42690

Organism names

Accessions

  • Primary accession
    A6TGK9

Proteomes

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10000172491-7545-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase

Proteomic databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the vitamin-B12 independent methionine synthase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    754
  • Mass (Da)
    84,504
  • Last updated
    2007-08-21 v1
  • Checksum
    A2A602DD35DC090F
MTIINHTLGFPRVGLRRELKKAQESYWAGNATREELLAVGRELRARHWEQQKQAGVDLLPVGDFAWYDHVLTTSLLLGNVPARHQNKDGSIDIDTLFRIGRGRAPTGEPAAAAEMTKWFNTNYHYMVPEFVKGQQFKLSWTQLLDEVDEALALGHKIKPVLLGPVTYLWLGKVKGEPFDRLTLLNTILPVYQQVLAELAKRGIDWVQIDEPALVLELPPAWLEAFQPAYDALQGQVKLLLTTYFEGVSDNLATIAALPVQGLHVDLVHGKDDVAELHNRLPADWLLSAGLINGRNVWRADLTEKYAQIKDLVGKRELWVASSCSLLHSPIDLSVETRLDAEVKSWFAFALQKCGELALLRDALNSGDTAAITEWSAPIQARRHSTRVHNAEVEKRLAAITAQDSQRASPYEVRAQAQRQRFNLPKWPTTTIGSFPQTTEIRGLRLDFKKGNLDASHYRTGIAEHIKQAIVEQERLGLDVLVHGEAERNDMVEYFGEHLDGFIFTQNGWVQSYGSRCVKPPVVIGDVSRPQAITVDWAKYAQSLTAKPVKGMLTGPVTILCWSFPREDVSRETIAKQIALALRDEVADLEAAGIGIIQIDEPALREGLPLKRSDWDAYLQWGVEAFRLNAAVAKDDTQIHTHMCYCEFNDIMDSIAALDADVITIETSRSDMELLESFEAFEYPNEIGPGVYDIHSPNVPSVEWIEALLKKAAQRIPVERLWVNPDCGLKTRGWPETRAALANMVQAARNLRQSA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000647
EMBL· GenBank· DDBJ
ABR79693.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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