A5ILT8 · NADA_THEP1
- ProteinQuinolinate synthase
- GenenadA
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids298 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
Catalytic activity
- iminosuccinate + dihydroxyacetone phosphate = quinolinate + phosphate + 2 H2O + H+This reaction proceeds in the forward direction.
Cofactor
Note: Binds 1 [4Fe-4S] cluster per subunit.
Pathway
Cofactor biosynthesis; NAD+ biosynthesis; quinolinate from iminoaspartate: step 1/1.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 19 | iminosuccinate (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 36 | iminosuccinate (UniProtKB | ChEBI) | ||||
Sequence: S | ||||||
Binding site | 81 | [4Fe-4S] cluster (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 107-109 | iminosuccinate (UniProtKB | ChEBI) | ||||
Sequence: YVN | ||||||
Binding site | 124 | iminosuccinate (UniProtKB | ChEBI) | ||||
Sequence: S | ||||||
Binding site | 168 | [4Fe-4S] cluster (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 193-195 | iminosuccinate (UniProtKB | ChEBI) | ||||
Sequence: HPE | ||||||
Binding site | 210 | iminosuccinate (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 254 | [4Fe-4S] cluster (UniProtKB | ChEBI) | ||||
Sequence: C |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | 4 iron, 4 sulfur cluster binding | |
Molecular Function | metal ion binding | |
Molecular Function | quinolinate synthetase A activity | |
Biological Process | 'de novo' NAD biosynthetic process from aspartate |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameQuinolinate synthase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Thermotogota > Thermotogae > Thermotogales > Thermotogaceae > Thermotoga
Accessions
- Primary accessionA5ILT8
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_1000061164 | 1-298 | Quinolinate synthase | |||
Sequence: MVDEILKLKKEKGYIILAHNYQIPELQDIADFVGDSLQLARKAMELSEKKILFLGVDFMAELVKILNPDKKVIVPDKSATCPMANRLTPEIIREYREKFPGAPVVLYVNSTSECKTLADVICTSANAVEVVKRLDSSVVIFGPDRNLGEYVAEKTGKKVITIPENGHCPVHQFNAESIDAVRKKYPDAKVIVHPESPKPVRDKADYVGSTGQMEKIPEKDPSRIFVIGTEIGMIHKLKKKFPDREFVPLEMAVCVNMKKNTLENTLHALQTESFEVILPKEVIEKAKKPILRMFELMG |
Interaction
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length298
- Mass (Da)33,543
- Last updated2007-06-26 v1
- ChecksumEDAEE7707929A577
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP000702 EMBL· GenBank· DDBJ | ABQ47161.1 EMBL· GenBank· DDBJ | Genomic DNA |