A5ILT8 · NADA_THEP1

Function

function

Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.

Catalytic activity

Cofactor

[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

Note: Binds 1 [4Fe-4S] cluster per subunit.

Pathway

Cofactor biosynthesis; NAD+ biosynthesis; quinolinate from iminoaspartate: step 1/1.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site19iminosuccinate (UniProtKB | ChEBI)
Binding site36iminosuccinate (UniProtKB | ChEBI)
Binding site81[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site107-109iminosuccinate (UniProtKB | ChEBI)
Binding site124iminosuccinate (UniProtKB | ChEBI)
Binding site168[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site193-195iminosuccinate (UniProtKB | ChEBI)
Binding site210iminosuccinate (UniProtKB | ChEBI)
Binding site254[4Fe-4S] cluster (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Function4 iron, 4 sulfur cluster binding
Molecular Functionmetal ion binding
Molecular Functionquinolinate synthetase A activity
Biological Process'de novo' NAD biosynthetic process from aspartate

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Quinolinate synthase
  • EC number

Gene names

    • Name
      nadA
    • Ordered locus names
      Tpet_1147

Organism names

Accessions

  • Primary accession
    A5ILT8

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10000611641-298Quinolinate synthase

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the quinolinate synthase family. Type 2 subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    298
  • Mass (Da)
    33,543
  • Last updated
    2007-06-26 v1
  • Checksum
    EDAEE7707929A577
MVDEILKLKKEKGYIILAHNYQIPELQDIADFVGDSLQLARKAMELSEKKILFLGVDFMAELVKILNPDKKVIVPDKSATCPMANRLTPEIIREYREKFPGAPVVLYVNSTSECKTLADVICTSANAVEVVKRLDSSVVIFGPDRNLGEYVAEKTGKKVITIPENGHCPVHQFNAESIDAVRKKYPDAKVIVHPESPKPVRDKADYVGSTGQMEKIPEKDPSRIFVIGTEIGMIHKLKKKFPDREFVPLEMAVCVNMKKNTLENTLHALQTESFEVILPKEVIEKAKKPILRMFELMG

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000702
EMBL· GenBank· DDBJ
ABQ47161.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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