A5I4X1 · AROE_CLOBH
- ProteinShikimate dehydrogenase (NADP(+))
- GenearoE
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids258 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
Catalytic activity
- NADP+ + shikimate = 3-dehydroshikimate + H+ + NADPH
Pathway
Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 14-16 | shikimate (UniProtKB | ChEBI) | ||||
Sequence: SES | ||||||
Binding site | 61 | shikimate (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Active site | 65 | Proton acceptor | ||||
Sequence: K | ||||||
Binding site | 86 | shikimate (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 101 | shikimate (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 125-129 | NADP+ (UniProtKB | ChEBI) | ||||
Sequence: GSGGS | ||||||
Binding site | 211 | NADP+ (UniProtKB | ChEBI) | ||||
Sequence: L | ||||||
Binding site | 213 | shikimate (UniProtKB | ChEBI) | ||||
Sequence: Y | ||||||
Binding site | 234 | NADP+ (UniProtKB | ChEBI) | ||||
Sequence: G |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | NADP binding | |
Molecular Function | shikimate 3-dehydrogenase (NADP+) activity | |
Biological Process | amino acid biosynthetic process | |
Biological Process | aromatic amino acid family biosynthetic process | |
Biological Process | chorismate biosynthetic process | |
Biological Process | shikimate metabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameShikimate dehydrogenase (NADP(+))
- EC number
- Short namesSDH
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Bacillota > Clostridia > Eubacteriales > Clostridiaceae > Clostridium
Accessions
- Primary accessionA5I4X1
- Secondary accessions
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_1000021275 | 1-258 | Shikimate dehydrogenase (NADP+) | |||
Sequence: MYTTGLIGKNINYSESPEIHNNYYKKNNIPFFYKIFNLKQDQIDDFIKNLHKNNIKGFNVTIPYKETILQYLNDIVYPADKIGAVNTVAVQEDKLIGYNTDYIGFIKSLQYYNIQVKNFKCLIIGSGGSAKCIYYALKELNARDICIVSRNPEKARLKFEKKVKILNIKDENKLDRYDLIVNCTPIGGPNLKEQKPIELKEIKKNCVVYDLNYTPKRSKLLKEAKENGAFIINGEKMLIFQAYSAIGLWCLNGIKGGR |
Interaction
Subunit
Homodimer.
Structure
Sequence
- Sequence statusComplete
- Length258
- Mass (Da)29,691
- Last updated2007-06-26 v1
- Checksum5BB7CDDE73F6FCF6
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP000727 EMBL· GenBank· DDBJ | ABS37187.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AM412317 EMBL· GenBank· DDBJ | CAL84094.1 EMBL· GenBank· DDBJ | Genomic DNA |