A4S3R2 · GUF1_OSTLU

Function

function

Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner.

Miscellaneous

This protein may be expected to contain an N-terminal transit peptide but none has been predicted.

Catalytic activity

Features

Showing features for binding site.

165150100150200250300350400450500550600650
TypeIDPosition(s)Description
Binding site60-67GTP (UniProtKB | ChEBI)
Binding site127-131GTP (UniProtKB | ChEBI)
Binding site181-184GTP (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionnucleotide bindingmolecular_functionnucleic acid bindingdna bindingchromatin bindingdna-binding transcription factor activityrna bindingcytoskeletal motor activitycatalytic activitynuclease activitysignaling receptor bindingstructural molecule activitytransporter activitybindingprotein bindingtranslation factor activity, rna bindinglipid bindingkinase activitytransferase activityhydrolase activityoxygen bindingenzyme regulator activitycarbohydrate bindingsignaling receptor activitytranslation regulator activitytranscription regulator activityother molecular functionall biological processcarbohydrate metabolic processgeneration of precursor metabolites and energynucleobase-containing compound metabolic processdna metabolic processtranslationlipid metabolic processtransportresponse to stresscell cyclecell communicationsignal transductioncell-cell signalingmulticellular organism developmentcircadian rhythmbiological_processmetabolic processcatabolic processbiosynthetic processresponse to light stimulusresponse to external stimulustropismresponse to biotic stimulusresponse to abiotic stimulusresponse to endogenous stimulusembryo developmentpost-embryonic developmentfruit ripeningabscissionpollinationflower developmentcellular processprogrammed cell deathphotosynthesiscellular component organizationcell growthprotein metabolic processcellular homeostasissecondary metabolic processreproductive processcell differentiationprotein modification processgrowthepigenetic regulation of gene expressionresponse to chemicalanatomical structure developmentregulation of molecular functionother biological processall cellular componentcellular_componentextracellular regioncell wallintracellular anatomical structurenucleusnuclear envelopenucleoplasmnucleoluscytoplasmmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuscytosolribosomecytoskeletonplasma membranechloroplastplastidthylakoidmembraneexternal encapsulating structureother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentmitochondrial matrix
Molecular FunctionGTP binding
Molecular FunctionGTPase activity
Molecular Functionmitochondrial ribosome binding
Biological Processpositive regulation of translation
Biological Processtranslation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Translation factor GUF1 homolog, mitochondrial
  • EC number
  • Alternative names
    • Elongation factor 4 homolog
      (EF-4
      )
    • GTPase GUF1 homolog
    • Ribosomal back-translocase

Gene names

    • ORF names
      OSTLU_88434

Organism names

Accessions

  • Primary accession
    A4S3R2

Proteomes

Genome annotation databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004028461-651Translation factor GUF1 homolog, mitochondrial

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain51-234tr-type G

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    651
  • Mass (Da)
    71,192
  • Last updated
    2007-05-15 v1
  • Checksum
    EF96BAE705144E55
MALRRVLVDRIVRSCAARAFASTSASYASARDALKEERPPTADELAAIPRERTRNFSIIAHVDHGKSTLADRLLELTGAIKRDGSNKQVLDTLPVERRRGITVKAQAVSILHREPSDGQAYLLNLIDTPGHADFSFEVSRSLSACDGAVMLVDATQGVEAQTIATFYLALDRNLAIVPAANKVDMTSADVERVAKQMERAFGVEREDVLEVSGKTGHNAEKVLSAVVKHVPHPSGDPNGPLRVLLLDCHYDDYRGAVNIVQVADGVIRKGDKVSSCASGQHFEVLELGMMTPERTKTDAMYAGQVGYMITNVRDVRSSKVGDTLHMKNEPVEPLAGIRPAKPMVFQGLYPVNSDDFEKLKAAVSKLTLNDASVTAQTENSTALGAGFRCGFLGLLHADVFHQRLQEEFGAEIIATAPTVPYRIKHANDEAYIDCTSPLAIPSGGFPSKGTEIEEPLVEATIICQPHVVGKVVELCMDRRGEQLEQNFLDDSRVILRYRLPLGEVAADFADELKSRSSGYATFDYDDAGMAKSDIVRMDVLVNGSVVDALATLVHRSKAQRHGRDLVARLKEALPRQLYEVALQAALGSKVIARETISAMRKNVTAKCYGGDISRKKKLLEKQKEGKRRMRRIGNVDIPNETFAGILSNKRN

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000590
EMBL· GenBank· DDBJ
ABO98431.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp