A4FXV6 · DAPB_METM5
- Protein4-hydroxy-tetrahydrodipicolinate reductase
- GenedapB
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids270 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
Catalytic activity
- (S)-2,3,4,5-tetrahydrodipicolinate + H2O + NAD+ = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H+ + NADH
Pathway
Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 4/4.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 8-13 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: GALGRM | ||||||
Binding site | 34 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 102-104 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: GTT | ||||||
Binding site | 128-131 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: SQNY | ||||||
Active site | 160 | Proton donor/acceptor | ||||
Sequence: H | ||||||
Binding site | 161 | (S)-2,3,4,5-tetrahydrodipicolinate (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Active site | 164 | Proton donor | ||||
Sequence: K | ||||||
Binding site | 170-171 | (S)-2,3,4,5-tetrahydrodipicolinate (UniProtKB | ChEBI) | ||||
Sequence: GT |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | 4-hydroxy-tetrahydrodipicolinate reductase | |
Molecular Function | NAD binding | |
Molecular Function | NADP binding | |
Molecular Function | oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor | |
Biological Process | diaminopimelate biosynthetic process | |
Biological Process | lysine biosynthetic process via diaminopimelate |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name4-hydroxy-tetrahydrodipicolinate reductase
- EC number
- Short namesHTPA reductase
Gene names
Organism names
- Strain
- Taxonomic lineageArchaea > Euryarchaeota > Methanomada group > Methanococci > Methanococcales > Methanococcaceae > Methanococcus
Accessions
- Primary accessionA4FXV6
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_1000008589 | 1-270 | 4-hydroxy-tetrahydrodipicolinate reductase | |||
Sequence: MVKVAVTGALGRMGSGIIKTITETDGLDVVAAIDIPNHPKKGLDIGELTGVGKIGVALSTSDELEVVLKESGAEVLVDFTAPAPCVNTAKTAAKLGVNLVIGTTGFTSEQRAEMENAISENKVAATISQNYAVGVNIFFKTLELLAQKLGDYDIELIEMHHKFKKDAPSGTALRAAEIIQNNLNRDSNLIFGRKGITGERTKEEICIHALRGGDVVGDHTAMFAADGERLELTHKASSRQSFISGVILAVKFVAEKKEGIYNTFDVLDLN |
Interaction
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length270
- Mass (Da)28,794
- Last updated2007-04-17 v1
- Checksum3AAE214F80523611
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP000609 EMBL· GenBank· DDBJ | ABO35040.1 EMBL· GenBank· DDBJ | Genomic DNA |