A3QBR5 · NHAA_SHELP
- ProteinNa(+)/H(+) antiporter NhaA
- GenenhaA
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids391 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Na+/H+ antiporter that extrudes sodium in exchange for external protons.
Catalytic activity
- Na+(in) + 2 H+(out) = Na+(out) + 2 H+(in)This reaction proceeds in the forward direction.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | sodium:proton antiporter activity | |
Biological Process | regulation of pH |
Keywords
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameNa(+)/H(+) antiporter NhaA
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Alteromonadales > Shewanellaceae > Shewanella
Accessions
- Primary accessionA3QBR5
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 14-34 | Helical | ||||
Sequence: AGGILLMAAVILAMIMANSPL | ||||||
Transmembrane | 59-79 | Helical | ||||
Sequence: LIHWINDGLMALFFMLIGLEV | ||||||
Transmembrane | 95-115 | Helical | ||||
Sequence: SLPTFAAIGGMIFPAAIYLIF | ||||||
Transmembrane | 124-144 | Helical | ||||
Sequence: VGWAIPAATDIAFALGIMALL | ||||||
Transmembrane | 154-174 | Helical | ||||
Sequence: VFLLALAIIDDLGVVVIIAMF | ||||||
Transmembrane | 177-197 | Helical | ||||
Sequence: TDLSAISLVVAALAIVILVGL | ||||||
Transmembrane | 213-233 | Helical | ||||
Sequence: LILWIAVLKSGVHATLAGVII | ||||||
Transmembrane | 261-281 | Helical | ||||
Sequence: FVILPIFAFANAGVDLSGMSL | ||||||
Transmembrane | 292-312 | Helical | ||||
Sequence: IALGLLLGKPLGVLLFSFVAV | ||||||
Transmembrane | 331-351 | Helical | ||||
Sequence: VAVMCGIGFTMSMFISSLAFI | ||||||
Transmembrane | 363-383 | Helical | ||||
Sequence: LGILTGSIMSAVIGYFWLSKV |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000334426 | 1-391 | Na+/H+ antiporter NhaA | |||
Sequence: MEKAIRNFLSQESAGGILLMAAVILAMIMANSPLSGLYQGFLHTEMQVRVGSLDIDKTLIHWINDGLMALFFMLIGLEVKRELLEGALSSREQASLPTFAAIGGMIFPAAIYLIFNYADPITQVGWAIPAATDIAFALGIMALLGSRVPVALKVFLLALAIIDDLGVVVIIAMFYSTDLSAISLVVAALAIVILVGLNRKGVTALAPYGVVGLILWIAVLKSGVHATLAGVIIAFCIPLRAKDGSSPSEHLEHSLHPWSTFVILPIFAFANAGVDLSGMSLGDLLSPVPVGIALGLLLGKPLGVLLFSFVAVKLKLAALPEGMGWRHIAPVAVMCGIGFTMSMFISSLAFIGDGEAYGDLARLGILTGSIMSAVIGYFWLSKVLPEKGEKS |
Interaction
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length391
- Mass (Da)41,245
- Last updated2007-04-17 v1
- ChecksumA42F89B8AD738241
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP000606 EMBL· GenBank· DDBJ | ABO22913.1 EMBL· GenBank· DDBJ | Genomic DNA |