A3PJQ3 · ISPD_CERS1
- Protein2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
- GeneispD
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids225 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).
Catalytic activity
- 2-C-methyl-D-erythritol 4-phosphate + CTP + H+ = 4-CDP-2-C-methyl-D-erythritol + diphosphate
Pathway
Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 2/6.
Features
Showing features for site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Site | 15 | Transition state stabilizer | ||||
Sequence: R | ||||||
Site | 22 | Transition state stabilizer | ||||
Sequence: K | ||||||
Site | 152 | Positions MEP for the nucleophilic attack | ||||
Sequence: R | ||||||
Site | 205 | Positions MEP for the nucleophilic attack | ||||
Sequence: K |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity | |
Biological Process | isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Alphaproteobacteria > Rhodobacterales > Paracoccaceae > Cereibacter
Accessions
- Primary accessionA3PJQ3
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_1000022943 | 1-225 | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase | |||
Sequence: MTTAAIIVAAGRGTRAGGDLPKQWQPLAGRPVLAHTLAAFRAAAGVSRTLLVIHPDDRARAEALPGVAEGKVELVEGGASRDASVRNALEALAGAGIERVLIHDGARPLVAPGLIARTLAALETAPGAAPAVPVSDALWRGEGGRVVGTQDRTGLFRAQTPQAFRYEAILAAHRAHPGGAADDVEVARAAGLEVAIVEGCEDNLKVTYPGDFARAERLLALAAGL |
Structure
Sequence
- Sequence statusComplete
- Length225
- Mass (Da)23,026
- Last updated2007-04-03 v1
- Checksum04558F8E98AA89FE
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP000577 EMBL· GenBank· DDBJ | ABN76569.1 EMBL· GenBank· DDBJ | Genomic DNA |