A3PGF5 · PDXJ_CERS1

Function

function

Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.

Catalytic activity

Pathway

Cofactor biosynthesis; pyridoxine 5'-phosphate biosynthesis; pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 5/5.

Features

Showing features for binding site, active site, site.

125220406080100120140160180200220240
TypeIDPosition(s)Description
Binding site123-amino-2-oxopropyl phosphate (UniProtKB | ChEBI)
Binding site14-151-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI)
Binding site233-amino-2-oxopropyl phosphate (UniProtKB | ChEBI)
Active site48Proton acceptor
Binding site501-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI)
Binding site551-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI)
Active site75Proton acceptor
Binding site1051-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI)
Site156Transition state stabilizer
Active site199Proton donor
Binding site2003-amino-2-oxopropyl phosphate (UniProtKB | ChEBI)
Binding site221-2223-amino-2-oxopropyl phosphate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionpyridoxine 5'-phosphate synthase activity
Biological Processpyridoxine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Pyridoxine 5'-phosphate synthase
  • EC number
  • Short names
    PNP synthase

Gene names

    • Name
      pdxJ
    • Ordered locus names
      Rsph17029_0305

Organism names

Accessions

  • Primary accession
    A3PGF5

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10000224011-252Pyridoxine 5'-phosphate synthase

Interaction

Subunit

Homooctamer; tetramer of dimers.

Structure

Family & Domains

Sequence similarities

Belongs to the PNP synthase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    252
  • Mass (Da)
    27,132
  • Last updated
    2007-04-03 v1
  • Checksum
    12878857ED43ECB1
MKPLGRLRLGVNIDHVATVRNARGTSYPDPLRAGLLAEAAGADGITAHLREDRRHIRDEDITALMQGLRVPLNLEMATTPEMQAIALRHKPHAVCLVPERREERTTEGGIDVAGDIGRLKDFVAPLRAAGCRVSMFIGHDVRQIEASAEIGAAVVELHTGHYCDLVAEGRTAEAARELEALREGAALAHSLGLEVHAGHGISYDTVAEIAAFPQVMELNIGHFLIGEAIFRGLGSAIEGMRRRMDAAREAAA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000577
EMBL· GenBank· DDBJ
ABN75421.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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