A3MA34 · RISB_ACIBT

Function

function

Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

Catalytic activity

Pathway

Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 1/2.

Features

Showing features for binding site, active site.

115620406080100120140
TypeIDPosition(s)Description
Binding site255-amino-6-(D-ribitylamino)uracil (UniProtKB | ChEBI)
Binding site59-615-amino-6-(D-ribitylamino)uracil (UniProtKB | ChEBI)
Binding site83-855-amino-6-(D-ribitylamino)uracil (UniProtKB | ChEBI)
Binding site88-89(2S)-2-hydroxy-3-oxobutyl phosphate (UniProtKB | ChEBI)
Active site91Proton donor
Binding site1165-amino-6-(D-ribitylamino)uracil (UniProtKB | ChEBI)
Binding site130(2S)-2-hydroxy-3-oxobutyl phosphate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentriboflavin synthase complex
Molecular Function6,7-dimethyl-8-ribityllumazine synthase activity
Biological Processriboflavin biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    6,7-dimethyl-8-ribityllumazine synthase
  • EC number
  • Short names
    DMRL synthase
    ; LS
    ; Lumazine synthase

Gene names

    • Name
      ribH
    • Ordered locus names
      A1S_3389

Organism names

Accessions

  • Primary accession
    A3MA34

Subcellular Location

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10000981551-1566,7-dimethyl-8-ribityllumazine synthase

Interaction

Subunit

Forms an icosahedral capsid composed of 60 subunits, arranged as a dodecamer of pentamers.

Structure

Family & Domains

Sequence similarities

Belongs to the DMRL synthase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    156
  • Mass (Da)
    16,493
  • Last updated
    2008-09-02 v2
  • Checksum
    AE8164D59C6BE50E
MAIRRIEGLLHLASEGRYAILVGRFNSFVVEHLLEGAIDTLKRHGVNEDNITVIHAPGAWELPIVAKKLATSNQFDAIIALGAVIRGSTPHFDFVAGECAKGLGVVALESSLPVINGVLTTDSIEQAIERSGTKAGNKGSEAALTAIEMVNLLKAI

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000521
EMBL· GenBank· DDBJ
ABO13778.2
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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