A2RG28 · MSRA_STRPG
- ProteinPeptide methionine sulfoxide reductase MsrA
- GenemsrA
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids169 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
Catalytic activity
- L-methionyl-[protein] + [thioredoxin]-disulfide + H2O = L-methionyl-(S)-S-oxide-[protein] + [thioredoxin]-dithiol
RHEA-COMP:12313 + RHEA-COMP:10700 CHEBI:50058 Position: n/n+3+ CHEBI:15377 = RHEA-COMP:12315 + RHEA-COMP:10698 CHEBI:29950 Position: nCHEBI:29950 Position: n+3
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 10 | |||||
Sequence: C |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | L-methionine:thioredoxin-disulfide S-oxidoreductase activity | |
Molecular Function | peptide-methionine (S)-S-oxide reductase activity | |
Biological Process | protein modification process |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePeptide methionine sulfoxide reductase MsrA
- EC number
- Short namesProtein-methionine-S-oxide reductase
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Bacillota > Bacilli > Lactobacillales > Streptococcaceae > Streptococcus
Accessions
- Primary accessionA2RG28
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_1000068368 | 1-169 | Peptide methionine sulfoxide reductase MsrA | |||
Sequence: MERAIFAGGCFWCMVQPFEEQAGILSVRSGYTGGHLPNPSYEQVCAKTTGHTEAVEIIFDPEEISYKELVELYWAQTDPTDAFGQFEDRGDNYRPVIYYTTERQKEIAEQSKANLQASGRFDQPIVTTIEPAEPFYLAEDYHQGFYKKNPKRYAQSSAIRHQFLEENWS |
Structure
Sequence
- Sequence statusComplete
- Length169
- Mass (Da)19,484
- Last updated2007-03-06 v1
- Checksum7800C67F3237891C
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AM295007 EMBL· GenBank· DDBJ | CAM30807.1 EMBL· GenBank· DDBJ | Genomic DNA |