A2BW42 · LPXD_PROM5
- ProteinUDP-3-O-acylglucosamine N-acyltransferase
- GenelpxD
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids344 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
Catalytic activity
- a (3R)-hydroxyacyl-[ACP] + a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine = a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + H+ + holo-[ACP]
Pathway
Bacterial outer membrane biogenesis; LPS lipid A biosynthesis.
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 248 | Proton acceptor | ||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | carboxysome | |
Molecular Function | N-acyltransferase activity | |
Molecular Function | structural constituent of carboxysome shell | |
Biological Process | lipid A biosynthetic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameUDP-3-O-acylglucosamine N-acyltransferase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Cyanobacteriota > Cyanophyceae > Synechococcales > Prochlorococcaceae > Prochlorococcus
Accessions
- Primary accessionA2BW42
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_1000050949 | 1-344 | UDP-3-O-acylglucosamine N-acyltransferase | |||
Sequence: MLLSKLVDLIKSGNSNFIKANIFENIDIQNAASLDVASKNQISFLEENNILKENLGRTAVSAIITFNNSEILGLLESKNISNIVVENPRIAFAEVLNYLYEQINFNPGIDDSVVMKESSKLGENCYLGPNVYIGENTVIGNNNKIFPGTTILGNVRLGDNNIIHPNCVIYENTRIENNCVINSNTVIGSEGFGFIPQDGKWIKMPQKGSVIIKSFVEIGTNCCVDRPSVGNTLIDEGTKIDNLVQIGHGVKIGKNCALAAQVGIAGGAVIGDGVILAGQVGVNNRVKVGNNVIASSKCGIHCDIEDGEVVSGFPAMKNKSWLRSSSIFKKLPELAKKLRQLDKK |
Interaction
Structure
Sequence
- Sequence statusComplete
- Length344
- Mass (Da)37,147
- Last updated2007-02-20 v1
- ChecksumF20E240C3D47E6F7
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP000552 EMBL· GenBank· DDBJ | ABM72003.1 EMBL· GenBank· DDBJ | Genomic DNA |