A2BQT3 · HIS4_PROMS
- Protein1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase
- GenehisA
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids255 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
Catalytic activity
- 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide
Pathway
Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9.
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 8 | Proton acceptor | ||||
Sequence: D | ||||||
Active site | 129 | Proton donor | ||||
Sequence: D |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity | |
Biological Process | L-histidine biosynthetic process | |
Biological Process | tryptophan biosynthetic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Cyanobacteriota > Cyanophyceae > Synechococcales > Prochlorococcaceae > Prochlorococcus
Accessions
- Primary accessionA2BQT3
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000290507 | 1-255 | 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase | |||
Sequence: MDLIPAIDLMNGKCVRLFKGDFNKRKDFAKEPHEQAEFWEREGAKYIHIVDLDAAKTGSPTNDKSIKKIAKTVNIPIQIGGGIRSQERIEQLFSYGVEKVIMGTSAIENKELVKDLSNKFPGRIIVGIDAKDGKVSTRGWLEQSNIFATDLVKEFSSFKIASFIVTDINTDGTLEGTNEEFIKSILEITDIPVIASGGVGSISDLLSLVKFENSGLFGVIVGKALYENKFTINEANNVLSAERLNDIDLNTNYYA |
Interaction
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length255
- Mass (Da)28,172
- Last updated2007-02-20 v1
- ChecksumF3ECF7C52AC59E53
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP000551 EMBL· GenBank· DDBJ | ABM70144.1 EMBL· GenBank· DDBJ | Genomic DNA |