A1RXN2 · PELO_THEPD
- ProteinProtein pelota homolog
- GenepelA
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids352 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.
Cofactor
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | endonuclease activity | |
Molecular Function | metal ion binding | |
Biological Process | nuclear-transcribed mRNA catabolic process, no-go decay | |
Biological Process | nuclear-transcribed mRNA catabolic process, non-stop decay | |
Biological Process | RNA surveillance |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameProtein pelota homolog
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageArchaea > Thermoproteota > Thermoprotei > Thermofilales > Thermofilaceae > Thermofilum
Accessions
- Primary accessionA1RXN2
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000361825 | 1-352 | Protein pelota homolog | |||
Sequence: MRVLGLNQERGEVELVVEVLEDLYYLFLLVRKGDVVYGWTTRQLRIERATGEERGERIPVYLGVEVEKVSYAKFSEKLRFTGRVVEAPEEVYAKGSFHTIQVGVGDRVKIVKKSGIDGFTRNILEKAASKIRRVLLISVGDEEVAVGYLSPVGVEVRAVVGYSPVGRGKESSLDERYREPIASIVQRIFESGRAEHVDEVVVAVNERLAEVVSRVLGELGVKARVVKVSEGGEAGIYELLRGGQSRELLSSVRLPLELAEVERVLQELFSGKGKAVAGLENVEKVAEWGIVKTLIVSDALLFGEESRERVLKVLGEVFSRNGKIFIVPEESEAGRKLKPFGGALAELYYSLE |
Interaction
Structure
Family & Domains
Domain
The N-terminal domain has the RNA-binding Sm fold. It harbors the endoribonuclease activity.
Sequence similarities
Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length352
- Mass (Da)38,990
- Last updated2009-02-10 v2
- Checksum20AE46FB6AB5B5AD
Sequence caution
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP000505 EMBL· GenBank· DDBJ | ABL77962.1 EMBL· GenBank· DDBJ | Genomic DNA | Different initiation |