A1RUC0 · NCPP_PYRIL

Function

function

Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA/RNA precursor pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Binds 1 divalent metal cation per subunit; can use either Mg2+ or Mn2+.

GO annotations

AspectTerm
Molecular FunctionITPase activity
Molecular Functionmetal ion binding
Molecular Functionnucleotide binding
Molecular Functionribonucleoside triphosphate phosphatase activity
Biological Processnucleotide metabolic process
Biological Processthiamine metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Probable inosine/xanthosine triphosphatase
  • EC number
  • Short names
    ITPase/XTPase
  • Alternative names
    • Non-canonical purine NTP phosphatase
    • Non-standard purine NTP phosphatase
    • Nucleoside-triphosphate phosphatase
      (NTPase
      )

Gene names

    • Ordered locus names
      Pisl_1392

Organism names

Accessions

  • Primary accession
    A1RUC0

Proteomes

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10000569561-177Probable inosine/xanthosine triphosphatase

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the YjjX NTPase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    177
  • Mass (Da)
    18,722
  • Last updated
    2007-02-06 v1
  • Checksum
    A0A8AF1A6B75778B
MIVAVASRNPNKLRAVQAAYKLFGMRAQVVPVEKPVSLPPQPIGVETVVAGAIERARAALSVVQNAEHGVGIEAGVLQAGGRYLDVTVAAIADRNGVVTIGFGPAFQVPDIFLNDVLRGVELGVLAERYFGRVAIGYKEGIIGVLTKGVVSRFDLNMAAVVMALVPRLSTNAPLYRF

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000504
EMBL· GenBank· DDBJ
ABL88552.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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