A1RUC0 · NCPP_PYRIL
- ProteinProbable inosine/xanthosine triphosphatase
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids177 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA/RNA precursor pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.
Catalytic activity
- XTP + H2O = XDP + phosphate + H+
Cofactor
Mn2+ (UniProtKB | Rhea| CHEBI:29035 )
Note: Binds 1 divalent metal cation per subunit; can use either Mg2+ or Mn2+.
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | ITPase activity | |
Molecular Function | metal ion binding | |
Molecular Function | nucleotide binding | |
Molecular Function | ribonucleoside triphosphate phosphatase activity | |
Biological Process | nucleotide metabolic process | |
Biological Process | thiamine metabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameProbable inosine/xanthosine triphosphatase
- EC number
- Short namesITPase/XTPase
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageArchaea > Thermoproteota > Thermoprotei > Thermoproteales > Thermoproteaceae > Pyrobaculum
Accessions
- Primary accessionA1RUC0
Proteomes
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_1000056956 | 1-177 | Probable inosine/xanthosine triphosphatase | |||
Sequence: MIVAVASRNPNKLRAVQAAYKLFGMRAQVVPVEKPVSLPPQPIGVETVVAGAIERARAALSVVQNAEHGVGIEAGVLQAGGRYLDVTVAAIADRNGVVTIGFGPAFQVPDIFLNDVLRGVELGVLAERYFGRVAIGYKEGIIGVLTKGVVSRFDLNMAAVVMALVPRLSTNAPLYRF |
Interaction
Structure
Sequence
- Sequence statusComplete
- Length177
- Mass (Da)18,722
- Last updated2007-02-06 v1
- ChecksumA0A8AF1A6B75778B
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP000504 EMBL· GenBank· DDBJ | ABL88552.1 EMBL· GenBank· DDBJ | Genomic DNA |