A1KST6 · KDSB_NEIMF
- Protein3-deoxy-manno-octulosonate cytidylyltransferase
- GenekdsB
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids253 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
Catalytic activity
- 3-deoxy-alpha-D-manno-oct-2-ulosonate + CTP = CMP-3-deoxy-beta-D-manno-octulosonate + diphosphate
Pathway
Nucleotide-sugar biosynthesis; CMP-3-deoxy-D-manno-octulosonate biosynthesis; CMP-3-deoxy-D-manno-octulosonate from 3-deoxy-D-manno-octulosonate and CTP: step 1/1.
Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | 3-deoxy-manno-octulosonate cytidylyltransferase activity | |
Biological Process | CMP-keto-3-deoxy-D-manno-octulosonic acid biosynthetic process | |
Biological Process | lipopolysaccharide biosynthetic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name3-deoxy-manno-octulosonate cytidylyltransferase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Betaproteobacteria > Neisseriales > Neisseriaceae > Neisseria
Accessions
- Primary accessionA1KST6
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000370106 | 1-253 | 3-deoxy-manno-octulosonate cytidylyltransferase | |||
Sequence: MTEFVVLIPARLDSSRLPGKALADIHGKPMVVRVAEQAAKSKAARVVVATDHPDIQTACQAHGIEVVMTSNRHESGTTRLAEASAALKLPPHLVVVNVQGDEPLIAPELIDRTAEVLVENNVQMATAAHELHDFDELMNPNAVKVVLDKNRNAIYFSRAPIPYPRDAMRAGKREMPSETAVLRHIGIYAYRAGFLQRYAEMSVSPLETIESLEQLRVLWHGYPIAVETAKEAPAAGVDTQEDLDRVRAVFQTV |
Structure
Sequence
- Sequence statusComplete
- Length253
- Mass (Da)27,810
- Last updated2007-02-06 v1
- Checksum5220B1522614D35D
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AM421808 EMBL· GenBank· DDBJ | CAM09917.1 EMBL· GenBank· DDBJ | Genomic DNA |