A1CM86 · MMM1_ASPCL
- ProteinMaintenance of mitochondrial morphology protein 1
- Genemmm1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids494 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. The mdm12-mmm1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all outer membrane beta-barrel proteins, and acts in a late step after the SAM complex. The mdm10-mdm12-mmm1 subcomplex further acts in the TOM40-specific pathway after the action of the mdm12-mmm1 complex. Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum membrane | |
Cellular Component | ERMES complex | |
Molecular Function | lipid binding | |
Biological Process | mitochondrial genome maintenance | |
Biological Process | mitochondrion-endoplasmic reticulum membrane tethering | |
Biological Process | phospholipid transport | |
Biological Process | protein insertion into mitochondrial outer membrane |
Keywords
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameMaintenance of mitochondrial morphology protein 1
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Eurotiomycetes > Eurotiomycetidae > Eurotiales > Aspergillaceae > Aspergillus > Aspergillus subgen. Fumigati
Accessions
- Primary accessionA1CM86
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Single-pass type I membrane protein
Note: The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-22 | Lumenal | ||||
Sequence: MSSQPGDPATLPAQSSLSFTQG | ||||||
Transmembrane | 23-43 | Helical | ||||
Sequence: FLLGQLSVVLVLAAFIKFFIF | ||||||
Topological domain | 44-494 | Cytoplasmic | ||||
Sequence: GEAPPPPSRGLSHRSATHRRSNSIYSNSPQEAGSRSLREKPSTSNVLRPVPSSSTNTRSILRKTYYSAIPTNPAKHGRLRIHHSSHQPESLDWFNVLIAQTIAQYRQTAYSLKDSPTSSILNSLTAALNNPEKKPAFIDKITVTDISLGEEFPIFSNCRIIAVDDPNSDGGRLQALMDVDLSDDNLSIAIETQLLLNYPKPCSAILPVALSISVVRFSGTLCISLVPASTPPLDTPSHSPSPPTADTATSGRSKPGDKAGGNQPRSNGSTEDPAGGNPPKTSPKSNVAFSFLPDYRLDLSVRSLIGSRSRLQDVPKVAQLVEARVQAWFEERVVEPRVQVVGLPDLWPRMGRTGVRTGDDAETASNGPRSTVSADIGGSARHEELAREPEALRFRGLLGARPPFDVASRTSSFNVETGDLRSRSMTRQESSGDLSDQLHIPGSLPEAVTPG |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000384212 | 1-494 | Maintenance of mitochondrial morphology protein 1 | |||
Sequence: MSSQPGDPATLPAQSSLSFTQGFLLGQLSVVLVLAAFIKFFIFGEAPPPPSRGLSHRSATHRRSNSIYSNSPQEAGSRSLREKPSTSNVLRPVPSSSTNTRSILRKTYYSAIPTNPAKHGRLRIHHSSHQPESLDWFNVLIAQTIAQYRQTAYSLKDSPTSSILNSLTAALNNPEKKPAFIDKITVTDISLGEEFPIFSNCRIIAVDDPNSDGGRLQALMDVDLSDDNLSIAIETQLLLNYPKPCSAILPVALSISVVRFSGTLCISLVPASTPPLDTPSHSPSPPTADTATSGRSKPGDKAGGNQPRSNGSTEDPAGGNPPKTSPKSNVAFSFLPDYRLDLSVRSLIGSRSRLQDVPKVAQLVEARVQAWFEERVVEPRVQVVGLPDLWPRMGRTGVRTGDDAETASNGPRSTVSADIGGSARHEELAREPEALRFRGLLGARPPFDVASRTSSFNVETGDLRSRSMTRQESSGDLSDQLHIPGSLPEAVTPG |
Interaction
Subunit
Homodimer. Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of mmm1, mdm10, mdm12 and mdm34. A mmm1 homodimer associates with one molecule of mdm12 on each side in a pairwise head-to-tail manner, and the SMP-LTD domains of mmm1 and mdm12 generate a continuous hydrophobic tunnel for phospholipid trafficking.
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 50-98 | Disordered | ||||
Sequence: PSRGLSHRSATHRRSNSIYSNSPQEAGSRSLREKPSTSNVLRPVPSSST | ||||||
Compositional bias | 60-98 | Polar residues | ||||
Sequence: THRRSNSIYSNSPQEAGSRSLREKPSTSNVLRPVPSSST | ||||||
Domain | 130-387 | SMP-LTD | ||||
Sequence: QPESLDWFNVLIAQTIAQYRQTAYSLKDSPTSSILNSLTAALNNPEKKPAFIDKITVTDISLGEEFPIFSNCRIIAVDDPNSDGGRLQALMDVDLSDDNLSIAIETQLLLNYPKPCSAILPVALSISVVRFSGTLCISLVPASTPPLDTPSHSPSPPTADTATSGRSKPGDKAGGNQPRSNGSTEDPAGGNPPKTSPKSNVAFSFLPDYRLDLSVRSLIGSRSRLQDVPKVAQLVEARVQAWFEERVVEPRVQVVGLP | ||||||
Region | 274-330 | Disordered | ||||
Sequence: PPLDTPSHSPSPPTADTATSGRSKPGDKAGGNQPRSNGSTEDPAGGNPPKTSPKSNV | ||||||
Compositional bias | 303-330 | Polar residues | ||||
Sequence: GGNQPRSNGSTEDPAGGNPPKTSPKSNV | ||||||
Region | 398-426 | Disordered | ||||
Sequence: VRTGDDAETASNGPRSTVSADIGGSARHE | ||||||
Compositional bias | 402-416 | Polar residues | ||||
Sequence: DDAETASNGPRSTVS | ||||||
Region | 449-494 | Disordered | ||||
Sequence: VASRTSSFNVETGDLRSRSMTRQESSGDLSDQLHIPGSLPEAVTPG | ||||||
Compositional bias | 450-480 | Polar residues | ||||
Sequence: ASRTSSFNVETGDLRSRSMTRQESSGDLSDQ |
Domain
The SMP-LTD domain is a barrel-like domain that can bind various types of glycerophospholipids in its interior and mediate their transfer between two adjacent bilayers.
Sequence similarities
Belongs to the MMM1 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length494
- Mass (Da)53,099
- Last updated2007-01-23 v1
- Checksum283DF95B427E2274
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 60-98 | Polar residues | ||||
Sequence: THRRSNSIYSNSPQEAGSRSLREKPSTSNVLRPVPSSST | ||||||
Compositional bias | 303-330 | Polar residues | ||||
Sequence: GGNQPRSNGSTEDPAGGNPPKTSPKSNV | ||||||
Compositional bias | 402-416 | Polar residues | ||||
Sequence: DDAETASNGPRSTVS | ||||||
Compositional bias | 450-480 | Polar residues | ||||
Sequence: ASRTSSFNVETGDLRSRSMTRQESSGDLSDQ |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
DS027058 EMBL· GenBank· DDBJ | EAW08673.1 EMBL· GenBank· DDBJ | Genomic DNA |