A0EQL2 · SHBG_CROCR

Function

function

Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration (By similarity).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular region
Molecular Functionsteroid binding

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Sex hormone-binding globulin
  • Short names
    SHBG

Gene names

    • Name
      SHBG

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Carnivora > Feliformia > Hyaenidae > Crocuta

Accessions

  • Primary accession
    A0EQL2

Subcellular Location

Secreted
Note: In testis, it is synthesized by the Sertoli cells, secreted into the lumen of the seminiferous tubule and transported to the epididymis.

Keywords

PTM/Processing

Features

Showing features for signal, chain, disulfide bond, glycosylation.

TypeIDPosition(s)Description
Signal1-27
ChainPRO_000027883328-393Sex hormone-binding globulin
Disulfide bond183↔208
Disulfide bond353↔381
Glycosylation371N-linked (GlcNAc...) asparagine
Glycosylation387N-linked (GlcNAc...) asparagine

Keywords

PTM databases

Interaction

Subunit

Homodimer.

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain35-208Laminin G-like 1
Domain215-381Laminin G-like 2

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    393
  • Mass (Da)
    42,443
  • Last updated
    2006-11-28 v1
  • Checksum
    F715EE01E60FDF57
MEGRGPLATSPRRRWLLLLLLLPHSHQRIQDPPAVHLSSASGQGPVTIMTFDFTKMRKTSSSFELRTWDPEGVILYGDTDPHEDWFMLGLRGGRPEIQIHNHVARLTVGAGPRLDDGKWHQVEVKVLGDLLLLTVDGEEVLCLKQVFGPLASRPQPVVRIAVGGLPFPPSSLRLPLVPALDGCVRRGSWLDHQAQTSVSALSGSPRSCGVESQPGSFFPPGAHAEFSLQDLPQPHAEPWAFSLDLGLQLAAGSGHLLALGTPENPPRLSLQLQDQKVVLSSAWGPQLHLPLVLGAPLQLKLAASGVTLSQGPETEILALPLSDPGSLLNLWVQPHARLFLGALPGEAASASFCLDGLWAQGQKLDMDRALNRSQNIWTHSCPQSLGNDTDTTH

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DQ285473
EMBL· GenBank· DDBJ
ABB89081.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

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