A0EQL2 · SHBG_CROCR
- ProteinSex hormone-binding globulin
- GeneSHBG
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids393 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score2/5
Function
function
Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration (By similarity).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | extracellular region | |
Molecular Function | steroid binding |
Keywords
- Ligand
Names & Taxonomy
Protein names
- Recommended nameSex hormone-binding globulin
- Short namesSHBG
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Carnivora > Feliformia > Hyaenidae > Crocuta
Accessions
- Primary accessionA0EQL2
Subcellular Location
UniProt Annotation
GO Annotation
Note: In testis, it is synthesized by the Sertoli cells, secreted into the lumen of the seminiferous tubule and transported to the epididymis.
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain, disulfide bond, glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-27 | |||||
Sequence: MEGRGPLATSPRRRWLLLLLLLPHSHQ | ||||||
Chain | PRO_0000278833 | 28-393 | Sex hormone-binding globulin | |||
Sequence: RIQDPPAVHLSSASGQGPVTIMTFDFTKMRKTSSSFELRTWDPEGVILYGDTDPHEDWFMLGLRGGRPEIQIHNHVARLTVGAGPRLDDGKWHQVEVKVLGDLLLLTVDGEEVLCLKQVFGPLASRPQPVVRIAVGGLPFPPSSLRLPLVPALDGCVRRGSWLDHQAQTSVSALSGSPRSCGVESQPGSFFPPGAHAEFSLQDLPQPHAEPWAFSLDLGLQLAAGSGHLLALGTPENPPRLSLQLQDQKVVLSSAWGPQLHLPLVLGAPLQLKLAASGVTLSQGPETEILALPLSDPGSLLNLWVQPHARLFLGALPGEAASASFCLDGLWAQGQKLDMDRALNRSQNIWTHSCPQSLGNDTDTTH | ||||||
Disulfide bond | 183↔208 | |||||
Sequence: CVRRGSWLDHQAQTSVSALSGSPRSC | ||||||
Disulfide bond | 353↔381 | |||||
Sequence: CLDGLWAQGQKLDMDRALNRSQNIWTHSC | ||||||
Glycosylation | 371 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 387 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N |
Keywords
- PTM
PTM databases
Interaction
Subunit
Homodimer.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 35-208 | Laminin G-like 1 | ||||
Sequence: VHLSSASGQGPVTIMTFDFTKMRKTSSSFELRTWDPEGVILYGDTDPHEDWFMLGLRGGRPEIQIHNHVARLTVGAGPRLDDGKWHQVEVKVLGDLLLLTVDGEEVLCLKQVFGPLASRPQPVVRIAVGGLPFPPSSLRLPLVPALDGCVRRGSWLDHQAQTSVSALSGSPRSC | ||||||
Domain | 215-381 | Laminin G-like 2 | ||||
Sequence: GSFFPPGAHAEFSLQDLPQPHAEPWAFSLDLGLQLAAGSGHLLALGTPENPPRLSLQLQDQKVVLSSAWGPQLHLPLVLGAPLQLKLAASGVTLSQGPETEILALPLSDPGSLLNLWVQPHARLFLGALPGEAASASFCLDGLWAQGQKLDMDRALNRSQNIWTHSC |
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length393
- Mass (Da)42,443
- Last updated2006-11-28 v1
- ChecksumF715EE01E60FDF57