A0A853G8X4 · A0A853G8X4_9GAMM

Function

function

Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

pyridoxal 5'-phosphate (UniProtKB | Rhea| CHEBI:597326 )

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; L-lysine from DL-2,6-diaminopimelate: step 1/1.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site238pyridoxal 5'-phosphate (UniProtKB | ChEBI)
Binding site270-273pyridoxal 5'-phosphate (UniProtKB | ChEBI)
Binding site273substrate
Binding site309substrate
Binding site313substrate
Active site340Proton donor
Binding site341substrate
Binding site368pyridoxal 5'-phosphate (UniProtKB | ChEBI)
Binding site368substrate

GO annotations

AspectTerm
Molecular Functiondiaminopimelate decarboxylase activity
Molecular Functionpyridoxal phosphate binding
Biological Processlysine biosynthetic process via diaminopimelate

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Diaminopimelate decarboxylase
  • EC number
  • Short names
    DAP decarboxylase
    ; DAPDC

Gene names

    • Name
      lysA
    • ORF names
      H0A74_03280

Organism names

Accessions

  • Primary accession
    A0A853G8X4

Proteomes

PTM/Processing

Features

Showing features for modified residue.

TypeIDPosition(s)Description
Modified residue59N6-(pyridoxal phosphate)lysine

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain35-277Orn/DAP/Arg decarboxylase 2 N-terminal
Domain278-366Orn/DAP/Arg decarboxylase 2 C-terminal

Sequence similarities

Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    413
  • Mass (Da)
    45,631
  • Last updated
    2021-09-29 v1
  • Checksum
    68263C84A2F36F31
MSFSYQNHILHAESVAIADLMKTYGSPLYVYSRTDIEYNWHLFSHAFGIHPHLVCYAVKANSNLAVLSVLAKIGSGFDVVSNGELERVLLAGADASRCVFSGVAKTNIEIKRALEVGIFCFNVESMAEMSRIEQVAKEMSMQAPISLRVNPDVDPKTHPYISTGLKENKFGVDIDDAIPIYKMAYNSPYLKVKGIDCHIGSQLTKISPFLDALDKVLELVAKLGKLNIHVTHLDLGGGVGIKYDNEQTIDINAYISSILDKVGSLKIILEPGRAIVGNAGIFVTKVEFLKQNSDKSFAIIDGAMNDLLRPSFYQAYHQVLPIDENAEGIDAHWDLVGPICETGDFLAKNRRLSLSEGDYLALMSAGAYGSTMSSNYNSRPRVAEVMVLGSQYTLVRERETIQDLFNKEYMIND

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JACCHU010000002
EMBL· GenBank· DDBJ
NYT52577.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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