A0A852K281 · A0A852K281_SPIPA

Function

function

Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmembrane
Molecular Functioncytokine receptor activity
Biological Processblood coagulation

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Tissue factor
  • Alternative names
    • Coagulation factor III

Gene names

    • Name
      F3
    • ORF names
      SPIPAS_R07508

Organism names

  • Taxonomic identifier
  • Strain
    • B10K-DU-023-52
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Neoaves > Telluraves > Australaves > Passeriformes > Passerellidae > Spizella

Accessions

  • Primary accession
    A0A852K281

Proteomes

Subcellular Location

Membrane
; Single-pass type I membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane220-242Helical

Keywords

  • Cellular component

PTM/Processing

Keywords

Interaction

Subunit

Interacts with HSPE; the interaction, inhibited by heparin, promotes the generation of activated factor X and activates coagulation in the presence of activated factor VII.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain4-78Fibronectin type-III
Domain101-207Interferon/interleukin receptor

Sequence similarities

Belongs to the tissue factor family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    263
  • Mass (Da)
    29,946
  • Last updated
    2021-09-29 v1
  • Checksum
    4152B158E42BC9A5
GYEDLPTAVNITWSSINFKTILQWQPKPSGYLYTVEIHGQTSDVKRKCIQTSETECDVTDALRNVKETYTAHILSVEPAKMDNFEEPPFEVSEKFTPYSQTVIGKPEIKEYSQKGSKLNVMFKDPLTPYIFPNGSFMSIQDIFQHDLEYKLYYWKDQSSGKKDVTTKSRNFEVSVDSGKNYCFYVQGIIPSRRENRNGQESRVLCTSGGRNILDEYGTEVFIILAVIAVAVITLAIVLPVVLCKRKKAKKARAVREKELLNGI

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue263

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
WBNQ01081640
EMBL· GenBank· DDBJ
NXX71154.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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