A0A851V282 · A0A851V282_9PASS
- ProteinPeptide-methionine (R)-S-oxide reductase
- GeneMsrb2
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids145 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residues.
Catalytic activity
- [thioredoxin]-disulfide + H2O + L-methionine = [thioredoxin]-dithiol + L-methionine (R)-S-oxide
RHEA-COMP:10700 CHEBI:50058 Position: n/n+3+ CHEBI:15377 + CHEBI:57844 = RHEA-COMP:10698 CHEBI:29950 Position: nCHEBI:29950 Position: n+3+ CHEBI:58773
Cofactor
Note: Binds 1 zinc ion per subunit.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | metal ion binding | |
Molecular Function | peptide-methionine (R)-S-oxide reductase activity | |
Biological Process | protein repair | |
Biological Process | response to oxidative stress |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePeptide-methionine (R)-S-oxide reductase
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Passeriformes > Muscicapidae > Copsychus
Accessions
- Primary accessionA0A851V282
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 14-143 | MsrB | ||||
Sequence: ATDWKKKLTPEQFYVTREKGTEPPFSGIYLNNTESGIYCCVCCNAPLFSSEKKYNSGTGWPSFSEAYGTCGRDESNTNIMRRPDNSLGSTRTEVVCKQCDAHLGHVFDDGPTPSGQRFCINSVSLNFKPG |
Sequence similarities
Belongs to the MsrB Met sulfoxide reductase family.
Family and domain databases
Sequence
- Sequence statusFragment
- Length145
- Mass (Da)15,776
- Last updated2021-09-29 v1
- Checksum915CA3BD70B6E0D2
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: D | ||||||
Non-terminal residue | 145 | |||||
Sequence: G |
Keywords
- Technical term