A0A851FID6 · A0A851FID6_PITSO

Function

function

Acts as an acyl-protein thioesterase. Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Acts as a palmitoyl thioesterase that catalyzes depalmitoylation of proteins, such as ADRB2, KCNMA1 and SQSTM1. Acts as a negative regulator of autophagy by mediating palmitoylation of SQSTM1, decreasing affinity between SQSTM1 and ATG8 proteins and recruitment of ubiquitinated cargo proteins to autophagosomes. Acts as a lysophospholipase and hydrolyzes lysophosphatidylcholine (lyso-PC). Also hydrolyzes lysophosphatidylethanolamine (lyso-PE), lysophosphatidylinositol (lyso-PI) and lysophosphatidylserine (lyso-PS). Has much higher thioesterase activity than lysophospholipase activity. Contributes to the production of lysophosphatidic acid (LPA) during blood coagulation by recognizing and cleaving plasma phospholipids to generate lysophospholipids which in turn act as substrates for ENPP2 to produce LPA.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum
Cellular Componentnuclear membrane
Cellular Componentplasma membrane
Molecular Functioncarboxylic ester hydrolase activity
Molecular Functionpalmitoyl-(protein) hydrolase activity
Biological Processprotein depalmitoylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Acyl-protein thioesterase 1
  • EC number
  • Alternative names
    • Lysophospholipase 1
    • Lysophospholipase I
    • Palmitoyl-protein hydrolase

Gene names

    • Name
      Lypla1
    • ORF names
      PITSOR_R08301

Organism names

  • Taxonomic identifier
  • Strain
    • B10K-DU-002-53
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Neoaves > Telluraves > Australaves > Passeriformes > Pittidae > Pitta

Accessions

  • Primary accession
    A0A851FID6

Proteomes

Subcellular Location

Keywords

PTM/Processing

Keywords

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain5-72Phospholipase/carboxylesterase/thioesterase

Sequence similarities

Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    77
  • Mass (Da)
    8,489
  • Last updated
    2021-09-29 v1
  • Checksum
    396008239541D653
QGPISGVNKDIPVLQCHGDCDPLVPLMFGSLTVEKLKSMINPANVTFKTYSGMMHSSSIEEMMDVKQFIDKHLPPVD

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue77

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
WEKX01021752
EMBL· GenBank· DDBJ
NWI94499.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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