A0A850RJJ5 · A0A850RJJ5_9GAMM

Function

function

Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • Release of an N-terminal amino acid, Xaa-|-Yaa-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Yaa may be Pro. Amino acid amides and methyl esters are also readily hydrolyzed, but rates on arylamides are exceedingly low.
    EC:3.4.11.1 (UniProtKB | ENZYME | Rhea)
  • Release of an N-terminal amino acid, preferentially leucine, but not glutamic or aspartic acids.
    EC:3.4.11.10 (UniProtKB | ENZYME | Rhea)

Cofactor

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Binds 2 manganese ions per subunit.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site268Mn2+ 2 (UniProtKB | ChEBI)
Binding site273Mn2+ 1 (UniProtKB | ChEBI)
Binding site273Mn2+ 2 (UniProtKB | ChEBI)
Active site280
Binding site291Mn2+ 2 (UniProtKB | ChEBI)
Binding site350Mn2+ 1 (UniProtKB | ChEBI)
Binding site352Mn2+ 1 (UniProtKB | ChEBI)
Binding site352Mn2+ 2 (UniProtKB | ChEBI)
Active site354

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionmanganese ion binding
Molecular Functionmetalloaminopeptidase activity
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Probable cytosol aminopeptidase
  • EC number
  • Alternative names
    • Leucine aminopeptidase
      (LAP
      ) (EC:3.4.11.10
      ) . EC:3.4.11.10 (UniProtKB | ENZYME | Rhea)
    • Leucyl aminopeptidase

Gene names

    • Name
      pepA
    • ORF names
      HW932_17465

Organism names

  • Taxonomic identifier
  • Strain
    • DSM 21881
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Chromatiales > Chromatiaceae > Allochromatium

Accessions

  • Primary accession
    A0A850RJJ5

Proteomes

Subcellular Location

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain348-355Cytosol aminopeptidase

Sequence similarities

Belongs to the peptidase M17 family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    498
  • Mass (Da)
    53,606
  • Last updated
    2021-09-29 v1
  • Checksum
    D7A6852D7CF2C541
MEFKIKTGALATHKTPCLVLGIFEKRKLSGPAERIDEASDGHLSRLLKKGDIEGEAGQTLMLYDLPGVTAERVLLIGLGKKKEFTRANYRKALAAATTLLQQSGAGEATLALPETLPNTLDLYTSVRDAVVTVEDKVYRYSHTRDDKRAPKTPLKRLNLWIGKKSETAQAERAARHGQAMAEGIRLARELGNLPGNVCTPSYLAEQARALGNQYPRLEVEVLEEDQMAELGMGALLSVSRGSRQPAKLIVMHYRGAPKETKPLVLVGKGLTFDAGGISLKPAAEMDEMKYDMAGGAAVIGALRAACELELPIHLIGVVPASENLPDGAANKPGDIVTSLSGQTIEILNTDAEGRLILCDALTYCERFDPEIVVDLATLTGACVVALGKHPAGLFTTDDRLAAELLAAGEAAGDRAWRMPLWEEYQSQLDSNFADMANVGGRDGGAITAACFLSRFTKKYRWAHLDIAGITWLTGKEKGGTGRPVALLTHWLLERAGQG

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JABZEO010000015
EMBL· GenBank· DDBJ
NVZ11050.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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