A0A847KRI3 · A0A847KRI3_9ACTO
- ProteinK(+)-insensitive pyrophosphate-energized proton pump
- GenehppA
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids842 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force.
Catalytic activity
- diphosphate + H+(in) + H2O = 2 H+(out) + 2 phosphate
Cofactor
Features
Showing features for site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Site | 536 | Determinant of potassium independence | ||||
Sequence: K |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | diphosphate hydrolysis-driven proton transmembrane transporter activity | |
Molecular Function | inorganic diphosphate phosphatase activity | |
Molecular Function | magnesium ion binding |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameK(+)-insensitive pyrophosphate-energized proton pump
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Actinomycetales
Accessions
- Primary accessionA0A847KRI3
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 38-60 | Helical | ||||
Sequence: LLALGLVVCVGGLLFGLASYLEI | ||||||
Transmembrane | 90-108 | Helical | ||||
Sequence: FLLVLWAFIAAVIIVYFKF | ||||||
Transmembrane | 114-139 | Helical | ||||
Sequence: WARMAIIVGFSLVGMAGSYAVAWYGI | ||||||
Transmembrane | 183-205 | Helical | ||||
Sequence: IMLLILLVVPPSLAGACFIGFAI | ||||||
Transmembrane | 293-316 | Helical | ||||
Sequence: ATLLVWIFVVRAVMVVASGLSYLA | ||||||
Transmembrane | 337-360 | Helical | ||||
Sequence: LTTLVWITSAVSIVATYATTWALL | ||||||
Transmembrane | 372-394 | Helical | ||||
Sequence: LATIISLGTVAGALIPELVKAFT | ||||||
Transmembrane | 415-446 | Helical | ||||
Sequence: LNILSGLVAGNFSAFWLGGAIIVLMAGAYLIS | ||||||
Transmembrane | 452-470 | Helical | ||||
Sequence: SLMIAPAVFAFGLVAFGFL | ||||||
Transmembrane | 542-567 | Helical | ||||
Sequence: VLIGTAVVGATTMIFSIIVALTGGLT | ||||||
Transmembrane | 579-599 | Helical | ||||
Sequence: PFLLGLVTGGAVIFWFTGASI | ||||||
Transmembrane | 645-662 | Helical | ||||
Sequence: MLNMFLGVFFATLAFAFI | ||||||
Transmembrane | 668-688 | Helical | ||||
Sequence: VGYLISIAVFGLYQAIFMANA | ||||||
Transmembrane | 730-751 | Helical | ||||
Sequence: VALNPVIKFTTLFGLLAVELAV | ||||||
Transmembrane | 757-778 | Helical | ||||
Sequence: GFGTLVLVLAGAFLAVTCYFVY |
Keywords
- Cellular component
Interaction
Subunit
Homodimer.
Structure
Family & Domains
Features
Showing features for region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 796-842 | Disordered | ||||
Sequence: AVLPPSGDGGHDAGVSPVPLDTGVDGRIRGVPAVAPAQPVLSGRNPR |
Sequence similarities
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length842
- Mass (Da)89,201
- Last updated2021-09-29 v1
- Checksum04B1A711BF2E6B9F