A0A835P1C8 · A0A835P1C8_9PASS

  • Protein
    Abasic site processing protein HMCES
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    2/5

Function

function

Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA: forms a stable thiazolidine linkage between a ring-opened abasic site and the alpha-amino and sulfhydryl substituents of its N-terminal catalytic cysteine residue. The HMCES DNA-protein cross-link is then either reversed or degraded. HMCES is able to catalyze the reversal of its thiazolidine cross-link and cycle between a cross-link and a non-cross-linked state depending on DNA context: mediates self-reversal of the thiazolidine cross-link in double stranded DNA, allowing APEX1 to initiate downstream repair of abasic sites. The HMCES DNA-protein cross-link can also be degraded by the SPRTN metalloprotease following unfolding by the BRIP1/FANCJ helicase. Acts as a protease: mediates autocatalytic processing of its N-terminal methionine in order to expose the catalytic cysteine.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Molecular Functionlyase activity
Molecular Functionpeptidase activity
Molecular Functionsingle-stranded DNA binding
Biological Processprotein-DNA covalent cross-linking repair
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Abasic site processing protein HMCES
  • EC number
  • Short names
    ES cell-specific 5hmC-binding protein
  • Alternative names
    • Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein
    • Peptidase HMCES
    • SRAP domain-containing protein 1

Gene names

    • ORF names
      IHE44_003264

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • SS15
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Passeriformes > Sturnidae > Lamprotornis

Accessions

  • Primary accession
    A0A835P1C8

Proteomes

PTM/Processing

Keywords

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region25-52Disordered
Region262-289Disordered
Region443-469Disordered

Sequence similarities

Belongs to the SOS response-associated peptidase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    469
  • Mass (Da)
    53,061
  • Last updated
    2021-09-29 v1
  • Checksum
    E7D58FAEE15F2526
MCGRTACSLAADNLRRACAYRDRRGQHRQPEWVRQERYQPSYNKGPQSSGPVLLSRRHLHQDADSSERVLMDMRWGLVPSWFKQDNPSKLQFNTSNCRSDTMLSKSSYKGALLKGKRCVVLADGFYEWQQQQNGGKQPYFIYFPQTKDAMDKEMEGDGEWKGWRLLTMAGIFDCWEPPGGGEMLMPAILDGDEAIRKWLDFAEVPTKEAVKLIQPTENIVFHPVSTFVNNIRNNTPECVARIELGAKKEVKATPSNKVMMGWLKSSQEGSPQKKENDLPNGWGSRDSQLQRSTRLRHQLRWLAIPFTADFPKQSEKWYFWKALQTGVEIIQASQGFCKQSQMLQTKSLTRNQYFLCVGNNKMGFTGWLCRALVHSVLTADEAFLKVTSSSGIHFRSPVAVEGVKMLSTSGGMLNFPSSGEHNPSRGDGGPMQRHRVQVISLQTVSTSSSIAKKKPNQNKTKRNNPTLSV

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JADDUC010000016
EMBL· GenBank· DDBJ
KAG0127311.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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