A0A832N488 · A0A832N488_9ARCH
- ProteinDNA polymerase II large subunit
- GenepolC
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1206 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.
Catalytic activity
- a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | 3'-5' exonuclease activity | |
Molecular Function | DNA binding | |
Molecular Function | DNA-directed DNA polymerase activity | |
Biological Process | DNA catabolic process | |
Biological Process | DNA-templated DNA replication |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDNA polymerase II large subunit
- EC number
- Short namesPol II
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageArchaea > Nanoarchaeota > Candidatus Nanoarchaeia > Nanoarchaeales > Nanopusillaceae
Accessions
- Primary accessionA0A832N488
Interaction
Subunit
Heterodimer of a large subunit and a small subunit.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 5-953 | DNA polymerase II large subunit DP2 N-terminal | ||||
Sequence: EYFQMIRKDVEKAYYVAKKARSLGYDPEPDVEIPISEDMADRVQNLVSIIDPIIKEISLPEAIRSIEKEFGPLTFSTILKISEYTAEKVYEKTKDKIRAIELGLRVGFAYHTLGVVAAPTEGIVKVLAKKRRDGKDYIAIYYAGPVRSAGGTPAAFSVIIADFLRRKFGFEKWDPTEEEIQRCIIEIYDYKRVAHLQYTPKREELEFVLKNLPVEVTGEATEDAEVSSYKDLPRIETNKIRGGMALVIAEGLCQKAGKLAKKFLEISKNFGLEEWSWLKKLKELQESLYSSSPSEGPKELISPSWKYLSQITAGRPVVSLPMEKGGFRLRYGKSRTNGHEAVSIHPATAILTLGFLAWGTQIVLERPGKAAGTTFSDTIEPPIVRLKDGSVIKVHSEKLARKLVEKNLIDKILFLGDILITYGDFLDNGHILAPSPYVEEWWVQELERKAHEKIQDFEVKFDMFKPRELFEITGIEKLAEFLEIKKERLEKIIKYPLKIKPTSIEALKISIKLDIPLHPKYTFFWKNINVKDLKELIEFLKENSEMLIKTTKIGNKEIKIAKEIKIPIDKVSEKIKGILEDILIEHKGKKGYIIISYPHSAALYIQLGYLEKIPEKENILDAINEISIVKIRDKVGIYIGARMGRPEKAKIREMKGSPMMLFPVGIEGGRMRNLIEALNTKGKVKSELSLYYCENCKVFTPYKKCAFCGSNTSKYYKCSVCNKFVKTKEHCGKPTKPYGKIAINLGKYIEISIKNLGIDISQLPKIIKGPRGLTSHEKYPERLEKGILRAKYGLFVFRDGTIRFDAIEIPITYFKPKDLVYVSIEKLKELGYTHDIYGNPLESEDQILELKPQDVILPTIGPTKKGGKIKKDGVVESLINTTKFIDELLERFYKLPKFYNVKKPEDLVGHLIIALAPHTSAGTVGRIIGFSRTQALLMHPLMHAAIRRN |
Sequence similarities
Belongs to the archaeal DNA polymerase II family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,206
- Mass (Da)137,531
- Last updated2021-09-29 v1
- ChecksumDCD0941448C9B331