A0A831XHJ8 · A0A831XHJ8_9DEIN

  • Protein
    Arginine biosynthesis bifunctional protein ArgJ
  • Gene
    argJ
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N2-acetylornithine and glutamate.

Miscellaneous

Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; L-ornithine and N-acetyl-L-glutamate from L-glutamate and N2-acetyl-L-ornithine (cyclic): step 1/1.
Amino-acid biosynthesis; L-arginine biosynthesis; N2-acetyl-L-ornithine from L-glutamate: step 1/4.

Features

Showing features for site, binding site, active site.

TypeIDPosition(s)Description
Site109Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Site110Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Binding site143substrate
Binding site165substrate
Site175-176Cleavage; by autolysis
Active site176Nucleophile
Binding site176substrate
Binding site255substrate
Binding site376substrate
Binding site381substrate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionglutamate N-acetyltransferase activity
Molecular FunctionL-glutamate N-acetyltransferase activity
Biological Processarginine biosynthetic process
Biological Processornithine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

Including 2 domains:

  • Recommended name
    Glutamate N-acetyltransferase
  • EC number
  • Alternative names
    • Ornithine acetyltransferase
      (OATase
      )
    • Ornithine transacetylase
  • Recommended name
    Amino-acid acetyltransferase
  • EC number
  • Alternative names
    • N-acetylglutamate synthase
      (AGSase
      )

Gene names

    • Name
      argJ
    • ORF names
      ENP09_05610

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • SpSt-189
  • Taxonomic lineage
    Bacteria > Deinococcota > Deinococci > Thermales > Thermaceae > Thermus

Accessions

  • Primary accession
    A0A831XHJ8

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_50331917461-175Arginine biosynthesis bifunctional protein ArgJ alpha chain
ChainPRO_5033191747176-381Arginine biosynthesis bifunctional protein ArgJ beta chain

Keywords

Interaction

Subunit

Heterotetramer of two alpha and two beta chains.

Family & Domains

Sequence similarities

Belongs to the ArgJ family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    381
  • Mass (Da)
    40,203
  • Last updated
    2021-09-29 v1
  • Checksum
    D2E4317FBA36DAFB
MAVRLPRGFRAGATQAGIKPSGKPDLALLVSGLPAAWAYAATQNRAAAPSIHRGRALYAQGGPLRAVVVNAGNANCATGERGFRDDARMAELAAQRLGVPPEEVLTASTGVIGVPLPVEKVELGLPQIALTPFAEAFAEAILTTDTAVKVAEREVAGARIVGMAKGSGMIHPSMATMLAFLVTDAKVPQEALREAWRGVVDRTFNQVTVDGDTSTNDLALLLANGAYGEVPLEDFFRAVEEVARELARRIARDGEGATKLMTVRVVGAATAEEARRAARAVAQSPLWKSALYGNDPNWGRILAALGNSGARFDPLRVRIALQGIPLYQGGALPFDREGASRAMRAEEVEVFVDLGEGEGEGEAFGCDLTEGYVRINALYTT

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DSHZ01000277
EMBL· GenBank· DDBJ
HEO42340.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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