A0A830G7U7 · A0A830G7U7_9EURY

  • Protein
    7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase
  • Gene
    cofG
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) from 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

Note: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

Pathway

Cofactor biosynthesis; coenzyme F0 biosynthesis.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site88[4Fe-4S] cluster (UniProtKB | ChEBI); 4Fe-4S-S-AdoMet
Binding site92[4Fe-4S] cluster (UniProtKB | ChEBI); 4Fe-4S-S-AdoMet
Binding site95[4Fe-4S] cluster (UniProtKB | ChEBI); 4Fe-4S-S-AdoMet

GO annotations

AspectTerm
Molecular Function4 iron, 4 sulfur cluster binding
Molecular Functionammonia-lyase activity
Molecular Functioniron ion binding
Molecular Functiontransferase activity, transferring alkyl or aryl (other than methyl) groups

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase
  • EC number
  • Alternative names
    • FO synthase subunit 1

Gene names

    • Name
      cofG
    • ORF names
      GCM10009021_02700

Organism names

  • Taxonomic identifier
  • Strain
    • JCM 16331
  • Taxonomic lineage
    Archaea > Euryarchaeota > Stenosarchaea group > Halobacteria > Halobacteriales > Halobacteriaceae

Accessions

  • Primary accession
    A0A830G7U7

Proteomes

Interaction

Subunit

The FO synthase complex consists of two subunits, CofG and CofH.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain74-310Radical SAM core

Sequence similarities

Belongs to the radical SAM superfamily. CofG family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    400
  • Mass (Da)
    43,580
  • Last updated
    2021-09-29 v1
  • Checksum
    0A4A5217DA3D6907
MPDIREGFALTGIKRAPLVAGRVAPVATFFGTDAVAPGVFPGIEAYDVDVTVAERDVRDALAVRPDDVAAADELSFARNVFLPLTTACRYTCTYCTYYDPPGQATLMTPEEIRETCRRGAAAGCTEALFTFGDDPDDRYTEIHDELADLGHDSIHTYLREACEIALEEGLLPHSNPGDQTYEEMGAVADVNASMGVMLETTAEVRAHGGPRSKVPGQRLNTIANAGKHGIPFTTGILVGLGETWRDRAESLLAIRELDRRYGHVQEVIVQPVTDNERWQEGSPSTATMRRAVAMARAVLPEGVSVQVPPNLMDARDVVDCGIDDLGGVSPVTDDHVNPEYAWPALRELEAVAEHAGVPLTERLPTYERYLDEAWLSERMLAALDATDEAGERYRAVRADP

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BMOQ01000001
EMBL· GenBank· DDBJ
GGN07120.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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