A0A830F190 · A0A830F190_9EURY
- Protein5-methylthioadenosine/S-adenosylhomocysteine deaminase
- GenemtaD
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids431 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L-homocysteine, respectively. Is also able to deaminate adenosine.
Catalytic activity
- H+ + H2O + S-adenosyl-L-homocysteine = NH4+ + S-inosyl-L-homocysteine
Cofactor
Note: Binds 1 zinc ion per subunit.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 60 | Zn2+ (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 62 | Zn2+ (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 89 | substrate | ||||
Sequence: E | ||||||
Binding site | 182 | substrate | ||||
Sequence: H | ||||||
Binding site | 209 | Zn2+ (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 212 | substrate | ||||
Sequence: E | ||||||
Binding site | 297 | Zn2+ (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 297 | substrate | ||||
Sequence: D |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | 5'-methylthioadenosine deaminase activity | |
Molecular Function | metal ion binding | |
Molecular Function | S-adenosylhomocysteine deaminase activity |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name5-methylthioadenosine/S-adenosylhomocysteine deaminase
- EC number
- Short namesMTA/SAH deaminase
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageArchaea > Euryarchaeota > Stenosarchaea group > Halobacteria > Halobacteriales > Halobacteriaceae
Accessions
- Primary accessionA0A830F190
Proteomes
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 51-398 | Amidohydrolase-related | ||||
Sequence: LVMPGLVNAHCHAAMTLLRGYADDKPLECWLREDVWPVEAELTAEDVRVGTELALVELIRSGTTAFADMYFEMAEVAEAVADAGVRARLGHGVVGVGKDADAARADHEESLAFAREYDGAADGRIRTVYAPHSLTTVSEELLREYVPDARAAGVPVHYHANETADEVDPVVEEHGERPLAYADDLGLLGESDFLAHGVHSDASEIALLAERGTAVVHCPASNMKLASGAAPVPAYREAGVTVALGTDGAASNNDLDLFDEMRDAAMLGKHAAADASAVPAQAAVEMATAGGADALGIDAGRVEAGRNADLAVVDFEAAHLTPTHDAVSHLAYAARGSDVRHTVCDGDV |
Sequence similarities
Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length431
- Mass (Da)45,069
- Last updated2021-09-29 v1
- ChecksumDB3F44E86C82C29A