A0A7X8DTW2 · A0A7X8DTW2_9FIRM

Function

function

CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Mg2+ or Mn2+ required for ssDNA cleavage activity.
[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

iron-sulfur cluster (UniProtKB | Rhea| CHEBI:30408 )

GO annotations

AspectTerm
Molecular Functionexonuclease activity
Molecular Functioniron-sulfur cluster binding
Molecular Functionmetal ion binding
Biological Processdefense response to virus

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    CRISPR-associated exonuclease Cas4
  • EC number

Gene names

    • Name
      cas4
    • ORF names
      GX327_02760

Organism names

  • Taxonomic identifier
  • Strain
    • AS23ysBPME_183
  • Taxonomic lineage
    Bacteria > Bacillota > Clostridia > Lachnospirales > Lachnospiraceae > Candidatus Epulonipiscium

Accessions

  • Primary accession
    A0A7X8DTW2

Proteomes

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain3-39DUF83
Domain93-190DUF83

Sequence similarities

Belongs to the CRISPR-associated exonuclease Cas4 family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    212
  • Mass (Da)
    25,220
  • Last updated
    2021-06-02 v1
  • Checksum
    843FB0D6C8A0B5BF
MISAIQHFYYCKRQWALIHMEQQWVENVHTVKGQILHEKVDDPFIFESRKDYFISRSMPLISYHLGFYGVADAVEFRLSKSGCYIPSKDNFYEIIPVEYKVGKPKEDNRDAIQLCVQAMCLEEMFQTTIEIGYLYYGKTRHRHLVQLNKLLRQEVYELSKEMHETLENDKTILAQYSTKCSNCSLYNICLPKIKKSYKSVKRYINIKLTEKE

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JAAYRK010000032
EMBL· GenBank· DDBJ
NLJ87695.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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