A0A7X8DTW2 · A0A7X8DTW2_9FIRM
- ProteinCRISPR-associated exonuclease Cas4
- Genecas4
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids212 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
Cofactor
Protein has several cofactor binding sites:
Mn2+ (UniProtKB | Rhea| CHEBI:29035 )
Note: Mg2+ or Mn2+ required for ssDNA cleavage activity.
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | exonuclease activity | |
Molecular Function | iron-sulfur cluster binding | |
Molecular Function | metal ion binding | |
Biological Process | defense response to virus |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCRISPR-associated exonuclease Cas4
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Bacillota > Clostridia > Lachnospirales > Lachnospiraceae > Candidatus Epulonipiscium
Accessions
- Primary accessionA0A7X8DTW2
Proteomes
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 3-39 | DUF83 | ||||
Sequence: SAIQHFYYCKRQWALIHMEQQWVENVHTVKGQILHEK | ||||||
Domain | 93-190 | DUF83 | ||||
Sequence: EIIPVEYKVGKPKEDNRDAIQLCVQAMCLEEMFQTTIEIGYLYYGKTRHRHLVQLNKLLRQEVYELSKEMHETLENDKTILAQYSTKCSNCSLYNICL |
Sequence similarities
Belongs to the CRISPR-associated exonuclease Cas4 family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length212
- Mass (Da)25,220
- Last updated2021-06-02 v1
- Checksum843FB0D6C8A0B5BF