A0A7X4X369 · A0A7X4X369_9VIBR

  • Protein
    2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase
  • Gene
    dapD
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route): step 1/3.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site204Mg2+ 2 (UniProtKB | ChEBI); ligand shared between trimeric partners
Active site220Acyl-anhydride intermediate
Binding site222succinyl-CoA (UniProtKB | ChEBI)
Binding site237succinyl-CoA (UniProtKB | ChEBI)
Binding site240succinyl-CoA (UniProtKB | ChEBI)
Binding site263succinyl-CoA (UniProtKB | ChEBI)
Binding site278-279succinyl-CoA (UniProtKB | ChEBI)
Binding site286succinyl-CoA (UniProtKB | ChEBI)
Binding site303succinyl-CoA (UniProtKB | ChEBI)
Binding site316-319succinyl-CoA (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Function2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity
Molecular Functionmagnesium ion binding
Biological Processdiaminopimelate biosynthetic process
Biological Processlysine biosynthetic process via diaminopimelate

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase
  • EC number
  • Alternative names
    • Tetrahydrodipicolinate N-succinyltransferase
      (THDP succinyltransferase
      ; THP succinyltransferase
      )
    • Tetrahydropicolinate succinylase

Gene names

    • Name
      dapD
    • ORF names
      CAG57_07460

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • V30_P3S12P165
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Vibrionales > Vibrionaceae > Vibrio

Accessions

  • Primary accession
    A0A7X4X369

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homotrimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain131-1712,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase middle

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    343
  • Mass (Da)
    35,756
  • Last updated
    2021-06-02 v1
  • Checksum
    3ADB664548BDC106
MANFALGFGTATKNRNGKIIEAFFPHPVLNPSDALVSALANISGYQQGNQALEISAEQSAQLANAFAANGQAANAALADKAAKSTQPLVLVILATDDKPQTVAEGFLKLQLISHRLVQPHGTVLEGIFGLLHNIAWTNEGPIDLPELAERQIDARLAGRSLSVDCVDKFPKMVDYIVPAGVRIADTARVRLGAHVGEGTTVMHEGFINFNAGTTGVSMVEGRISAGVMVGNGSDIGGGASIMGTLSGGGKVVVSIGENSLLGANAGLGFPLGDRCTIESGLYVTAGTKVRMLDKEGNEVETIKARELAGVSDLLFRRNSQTGQVECLANKSAVQLNSELHSNN

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
WXWH01000036
EMBL· GenBank· DDBJ
NAX05007.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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