A0A7X4X2I1 · A0A7X4X2I1_9VIBR

Function

function

Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • Endonucleolytic cleavage to 5'-phosphooligonucleotide end-products.
    EC:3.1.21.2 (UniProtKB | ENZYME | Rhea)

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 3 Zn2+ ions.

Features

Showing features for binding site.

129520406080100120140160180200220240260280
TypeIDPosition(s)Description
Binding site78Zn2+ 1 (UniProtKB | ChEBI)
Binding site118Zn2+ 1 (UniProtKB | ChEBI)
Binding site154Zn2+ 1 (UniProtKB | ChEBI)
Binding site154Zn2+ 2 (UniProtKB | ChEBI)
Binding site188Zn2+ 2 (UniProtKB | ChEBI)
Binding site191Zn2+ 3 (UniProtKB | ChEBI)
Binding site225Zn2+ 2 (UniProtKB | ChEBI)
Binding site238Zn2+ 3 (UniProtKB | ChEBI)
Binding site240Zn2+ 3 (UniProtKB | ChEBI)
Binding site270Zn2+ 2 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functiondeoxyribonuclease IV (phage-T4-induced) activity
Molecular FunctionDNA binding
Molecular Functionzinc ion binding
Biological ProcessDNA repair

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Probable endonuclease 4
  • EC number
  • Alternative names
    • Endodeoxyribonuclease IV
    • Endonuclease IV

Gene names

    • Name
      nfo
    • ORF names
      CAG57_05550

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • V30_P3S12P165
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Vibrionales > Vibrionaceae > Vibrio

Accessions

  • Primary accession
    A0A7X4X2I1

Proteomes

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain29-286Xylose isomerase-like TIM barrel

Sequence similarities

Belongs to the AP endonuclease 2 family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    295
  • Mass (Da)
    32,922
  • Last updated
    2021-06-02 v1
  • Checksum
    7914BAA57A70F94E
MTNDKNGSQEKFFGAHVSAAGGVDQAPIRAKQIGANAFALFTKNQRQWGGKPLDAETIRAFKLNCQQLGFSTQHILPHDSYLINLGAPEQDKLAKSRQAFIEEMERCQQLGLTLLNFHPGSHLKQISEAQCLSTIAESINLAHQAVPNVIAVIENTAGQGSNLGWRFEHLAEIIAQIDDQSRVGVCLDTCHTFAAGYDLRSQAACEETFAQFEQVVGMHYLRAMHINDSKSKLGSRVDRHHSLGQGEIGWACFEYIAQDPRFNGIPLILETIDPELWPKEIETLKRFHRGDRFLD

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
WXWH01000028
EMBL· GenBank· DDBJ
NAX04632.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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