A0A7X4X2I1 · A0A7X4X2I1_9VIBR
- ProteinProbable endonuclease 4
- Genenfo
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids295 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.
Catalytic activity
Cofactor
Note: Binds 3 Zn2+ ions.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 78 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 118 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 154 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 154 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 188 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 191 | Zn2+ 3 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 225 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 238 | Zn2+ 3 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 240 | Zn2+ 3 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 270 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: E |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | deoxyribonuclease IV (phage-T4-induced) activity | |
Molecular Function | DNA binding | |
Molecular Function | zinc ion binding | |
Biological Process | DNA repair |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameProbable endonuclease 4
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Vibrionales > Vibrionaceae > Vibrio
Accessions
- Primary accessionA0A7X4X2I1
Proteomes
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 29-286 | Xylose isomerase-like TIM barrel | ||||
Sequence: RAKQIGANAFALFTKNQRQWGGKPLDAETIRAFKLNCQQLGFSTQHILPHDSYLINLGAPEQDKLAKSRQAFIEEMERCQQLGLTLLNFHPGSHLKQISEAQCLSTIAESINLAHQAVPNVIAVIENTAGQGSNLGWRFEHLAEIIAQIDDQSRVGVCLDTCHTFAAGYDLRSQAACEETFAQFEQVVGMHYLRAMHINDSKSKLGSRVDRHHSLGQGEIGWACFEYIAQDPRFNGIPLILETIDPELWPKEIETLKR |
Sequence similarities
Belongs to the AP endonuclease 2 family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length295
- Mass (Da)32,922
- Last updated2021-06-02 v1
- Checksum7914BAA57A70F94E