A0A7W8QQ12 · A0A7W8QQ12_9ACTN
- Proteinproline dehydrogenase
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids308 (go to sequence)
- Protein existencePredicted
- Annotation score2/5
Function
Catalytic activity
- a quinone + L-proline = (S)-1-pyrroline-5-carboxylate + a quinol + H+
Cofactor
Note: Binds 1 FAD per subunit.
Pathway
Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 1/2.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 97 | substrate | ||||
Sequence: K | ||||||
Binding site | 135 | FAD (UniProtKB | ChEBI) | ||||
Sequence: M | ||||||
Binding site | 163 | FAD (UniProtKB | ChEBI) | ||||
Sequence: Q | ||||||
Binding site | 187-189 | FAD (UniProtKB | ChEBI) | ||||
Sequence: KGA | ||||||
Binding site | 201 | FAD (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 226-227 | FAD (UniProtKB | ChEBI) | ||||
Sequence: SH | ||||||
Binding site | 288 | substrate | ||||
Sequence: R | ||||||
Binding site | 289 | substrate | ||||
Sequence: R |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | nucleotide binding | |
Molecular Function | proline dehydrogenase activity | |
Biological Process | proline catabolic process to glutamate |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameproline dehydrogenase
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Streptosporangiales > Nocardiopsaceae > Nocardiopsis
Accessions
- Primary accessionA0A7W8QQ12
Proteomes
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 45-299 | Proline dehydrogenase | ||||
Sequence: VAELSRDRYVTLDHLGEDTTDEAQAQNTVKAYTRLLEELGRAGLGGRAEVSVKLSAVGQFLPADGEKIALDNARAICEAAAAIGTTVTLDMEDHTTVDSTLSVLRELRTDFPWVGAVLQAYLYRTEADCRDLAGAGSRVRLCKGAYDEPASVAFRDKAEVDRSYVRCMKVLMNGEGYPMIASHDPRMVAIAQQLAATAGRSEDDYEHQMLYGIRDDEQERLAAEGRRMRVYVPYGTEWYGYYMRRLAERPANMLF |
Family and domain databases
Sequence
- Sequence statusComplete
- Length308
- Mass (Da)34,242
- Last updated2021-06-02 v1
- Checksum5B8AFEAA780C43E8
Keywords
- Technical term