A0A7W3V1P0 has been merged into A0A0R0BRM3. You have automatically been redirected. To see A0A7W3V1P0's history, click here.

A0A0R0BRM3 · A0A0R0BRM3_9GAMM

Function

function

Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Pathway

Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 1/4.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site15Mn2+ (UniProtKB | ChEBI)
Binding site203Mn2+ (UniProtKB | ChEBI)
Binding site205Mn2+ (UniProtKB | ChEBI)
Binding site239Mn2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Function2-isopropylmalate synthase activity
Molecular Functionacetyl-CoA C-acetyltransferase activity
Molecular Functionmanganese ion binding
Biological ProcessL-leucine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    2-isopropylmalate synthase
  • EC number
  • Alternative names
    • Alpha-IPM synthase
    • Alpha-isopropylmalate synthase

Gene names

    • Name
      leuA
    • ORF names
      ABB25_11570
      , H4O09_12455

Organism names

  • Taxonomic identifier
  • Strains
    • DSM 17805
    • W1S232
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Lysobacterales > Lysobacteraceae > Stenotrophomonas

Accessions

  • Primary accession
    A0A0R0BRM3
  • Secondary accessions
    • A0A7W3V1P0

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain6-268Pyruvate carboxyltransferase
Region390-512Regulatory domain

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    512
  • Mass (Da)
    55,363
  • Last updated
    2016-01-20 v1
  • Checksum
    3BB5B472C40B4ABB
MTTDRIRIFDTTLRDGEQSPGCSMSPQQKLVMARALTELGVDIIETGFAASSQSDREALALIAAELKTPVLATLSRCLPGDIETSVKALETAARPRLHVFLSTSPLHREHKLRMSKEQILESVHTHVRLARSYIDDIEFSAEDATRTELDFLTEVAQVAIAAGATTINLPDTVGFTTPEEIRNMFAHVIANAAGSDKVIFSAHCHNDLGLAVANSLAAIEGGARQVEGSINGIGERAGNCAIEEIVMALKVRNAFYGHDTGIDTRRIVATSQLLQRLVGMPVQRNKAIVGANAFAHESGIHQHGMLRNRNTYEIMRPEDVGWESSQMVLGRHSGRAAVEARLRALGYWLEEEELALVFEQFKALCEQQRVVTDIDLQTLMHGAPVQDGYRLASMTISDVGQRANALVELSDPEGNRVCETASGDGPVDALFAALSAATGVALSLDSYHVHSVGIGADARGEANLSVRHEGEAYEGTGTSRDVIEASALAWLDVANRLLRQRQGSRQAETSNA

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LDJH01000022
EMBL· GenBank· DDBJ
KRG55747.1
EMBL· GenBank· DDBJ
Genomic DNA
JACIUV010000005
EMBL· GenBank· DDBJ
MBB1117863.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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