A0A7W1BF40 · A0A7W1BF40_9BACT

  • Protein
    DNA-directed RNA polymerase subunit alpha
  • Gene
    rpoA
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular ComponentDNA-directed RNA polymerase complex
Molecular FunctionDNA binding
Molecular FunctionDNA-directed 5'-3' RNA polymerase activity
Molecular Functionprotein dimerization activity
Biological ProcessDNA-templated transcription

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    DNA-directed RNA polymerase subunit alpha
  • EC number
  • Short names
    RNAP subunit alpha
  • Alternative names
    • RNA polymerase subunit alpha
    • Transcriptase subunit alpha

Gene names

    • Name
      rpoA
    • ORF names
      H0W29_11765

Organism names

Accessions

  • Primary accession
    A0A7W1BF40

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

Family & Domains

Features

Showing features for region, domain.

TypeIDPosition(s)Description
Region1-241Alpha N-terminal domain (alpha-NTD)
Domain25-234DNA-directed RNA polymerase RpoA/D/Rpb3-type
Region255-351Alpha C-terminal domain (alpha-CTD)

Domain

The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

Sequence similarities

Belongs to the RNA polymerase alpha chain family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    351
  • Mass (Da)
    38,834
  • Last updated
    2021-06-02 v1
  • Checksum
    8AED94AF71296C82
MTIDLTGLVRPHLVEMTKRDDNPNAAEFRLQPLERGFGYTLGNSLRRLLLSSLRGSAVWGFRLDGVVHEHQTVLGVLEDVHQIVQRLKALTLVVAEDVDDAVLHIRREGAGPVYARDIQEHGAVTLKNPDHLLFTLQDDREVSMELYVNKGRGYVEAEMHPADRSLPVDLVRIDAIYNPVRRANFTVAETRVGQRTDYDRLTVSVETNGTITPEDAIAYAAALAQVHFQYFVDFGKVPTMRDAGAAPSASGGANLRQRLSRPIDDFGLSVRSLNSLKNSNIRTLKDLVEFSEDDLLKVKNVGEKALTEIAELLQREGLNFGMGFEETDGELRILRPGVAPMAQPSAGTGEV

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JACDCL010000422
EMBL· GenBank· DDBJ
MBA3555423.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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