A0A7T8G5Y0 · A0A7T8G5Y0_TAMSI

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

Cu cation (UniProtKB | Rhea| CHEBI:23378 )

Note: Binds a copper A center.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentrespirasome
Molecular Functioncopper ion binding
Molecular Functioncytochrome-c oxidase activity
Biological ProcessATP synthesis coupled electron transport

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 2

Gene names

    • Name
      COII

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Strains
    • HBSJ01
    • HBSJ02
    • HBSJ03
    • HBSJ04
    • HBSJ05
    • HBSJ06
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Sciuromorpha > Sciuridae > Xerinae > Marmotini > Tamias

Accessions

  • Primary accession
    A0A7T8G5Y0

Subcellular Location

Membrane
; Multi-pass membrane protein
Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane27-46Helical
Transmembrane66-85Helical

Keywords

Interaction

Subunit

Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI1III2IV1 and megacomplex MCI2III2IV2) (By similarity).
Found in a complex with TMEM177, COA6, COX18, COX20, SCO1 and SCO2. Interacts with TMEM177 in a COX20-dependent manner. Interacts with COX20. Interacts with COX16

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-91Cytochrome oxidase subunit II transmembrane region profile
Domain92-225Cytochrome oxidase subunit II copper A binding

Sequence similarities

Belongs to the cytochrome c oxidase subunit 2 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    228
  • Mass (Da)
    26,104
  • Last updated
    2021-06-02 v1
  • Checksum
    2BAEAED53C7A244C
MAYPFELGFQDATSPIMEELLHFHDHTLMIVFLISSLVLYIISLMLTTKLTHTSTMDAQEVETIWTILPAIILILIALPSLRILYMMDEINDPSLTVKTMGHQWYWSYEYTDYEDLNFDSYMIPTSDLNPGELRLLEVDNRMVLPMELPVRMLISSEDVLHSWAVPSLGLKTDAIPGRLNQATLISTRPGLYYGQCSEICGSNHSFMPIVLELVPLKHFENWSSSMLN

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue228

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MT109552
EMBL· GenBank· DDBJ
QQP23384.1
EMBL· GenBank· DDBJ
Genomic DNA
MT109553
EMBL· GenBank· DDBJ
QQP23385.1
EMBL· GenBank· DDBJ
Genomic DNA
MT109554
EMBL· GenBank· DDBJ
QQP23386.1
EMBL· GenBank· DDBJ
Genomic DNA
MT109555
EMBL· GenBank· DDBJ
QQP23387.1
EMBL· GenBank· DDBJ
Genomic DNA
MT109556
EMBL· GenBank· DDBJ
QQP23388.1
EMBL· GenBank· DDBJ
Genomic DNA
MT109557
EMBL· GenBank· DDBJ
QQP23389.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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