A0A7S7YE53 · A0A7S7YE53_9NEIS

  • Protein
    Enterobactin synthase component D
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    2/5

Function

function

Involved in the biosynthesis of the siderophore enterobactin (enterochelin), which is a macrocyclic trimeric lactone of N-(2,3-dihydroxybenzoyl)-serine. The serine trilactone serves as a scaffolding for the three catechol functionalities that provide hexadentate coordination for the tightly ligated iron2+ atoms. Plays an essential role in the assembly of the enterobactin by catalyzing the transfer of the 4'-phosphopantetheine (Ppant) moiety from coenzyme A to the apo-domains of both EntB (ArCP domain) and EntF (PCP domain) to yield their holo-forms which make them competent for the activation of 2,3-dihydroxybenzoate (DHB) and L-serine, respectively.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Pathway

Siderophore biosynthesis; enterobactin biosynthesis.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site59CoA (UniProtKB | ChEBI)
Binding site67CoA (UniProtKB | ChEBI)
Binding site102-103CoA (UniProtKB | ChEBI)
Binding site124CoA (UniProtKB | ChEBI)
Binding site124Mg2+ (UniProtKB | ChEBI)
Binding site125Mg2+ (UniProtKB | ChEBI)
Binding site126Mg2+ (UniProtKB | ChEBI)
Binding site168CoA (UniProtKB | ChEBI)
Binding site172CoA (UniProtKB | ChEBI)
Binding site182CoA (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componententerobactin synthetase complex
Molecular Functionholo-[acyl-carrier-protein] synthase activity
Molecular Functionmagnesium ion binding
Biological Processenterobactin biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Enterobactin synthase component D
  • Alternative names
    • 4'-phosphopantetheinyl transferase EntD
    • Enterochelin synthase D

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • DSM 17726
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Betaproteobacteria > Neisseriales > Chitinibacteraceae > Chitinimonas

Accessions

  • Primary accession
    A0A7S7YE53

Subcellular Location

Interaction

Subunit

EntB, EntD, EntE, and EntF form a multienzyme complex called enterobactin synthase.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain52-1134'-phosphopantetheinyl transferase N-terminal
Domain121-2104'-phosphopantetheinyl transferase

Sequence similarities

Belongs to the P-Pant transferase superfamily. EntD family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    241
  • Mass (Da)
    25,996
  • Last updated
    2021-06-02 v1
  • Checksum
    0F464770627E77AD
MIALTADASAPDFALPDLCMVRCGFAYDAAGLAGETALRAPDGTWLALPADLQRAVPKRQAEYLAGRWCAARALRRFAAAEQVAVQPDRSPGWPAGFVGSISHAQGRALAVVARGDDYRALGVDIETELDPATAAQLEPMLLQADETALRPAGWPQARFLTLAFSAKETLYKAVYPHGRRILEFHDARLLAIGAGELELALLPDHRPATLPDARYRVAYRFDGNQCLTLLALPQHAMATVP

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MW160162
EMBL· GenBank· DDBJ
QPB41101.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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