A0A7S6TAM9 · A0A7S6TAM9_9MURI

Function

function

Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.

Cofactor

Protein has several cofactor binding sites:
heme b (UniProtKB | Rhea| CHEBI:60344 )

Note: Binds 2 heme groups non-covalently.
heme (UniProtKB | Rhea| CHEBI:30413 )

Note: Binds 2 heme groups non-covalently.

Features

Showing features for binding site.

138150100150200250300350
TypeIDPosition(s)Description
Binding site83Fe (UniProtKB | ChEBI) of heme b b562 (UniProtKB | ChEBI); axial binding residue
Binding site97Fe (UniProtKB | ChEBI) of heme b b566 (UniProtKB | ChEBI); axial binding residue
Binding site182Fe (UniProtKB | ChEBI) of heme b b562 (UniProtKB | ChEBI); axial binding residue
Binding site196Fe (UniProtKB | ChEBI) of heme b b566 (UniProtKB | ChEBI); axial binding residue
Binding site201a ubiquinone (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentmitochondrial respiratory chain complex III
Molecular Functionmetal ion binding
Molecular Functionubiquinol-cytochrome-c reductase activity
Biological Processmitochondrial electron transport, ubiquinol to cytochrome c

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome b

Gene names

    • Name
      CYTB

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Aethomys

Accessions

  • Primary accession
    A0A7S6TAM9

Subcellular Location

Membrane
; Multi-pass membrane protein
Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane30-52Helical
Transmembrane87-107Helical
Transmembrane113-133Helical
Transmembrane145-166Helical
Transmembrane178-200Helical
Transmembrane229-247Helical
Transmembrane288-307Helical
Transmembrane319-340Helical
Transmembrane346-368Helical

Keywords

Interaction

Subunit

The cytochrome bc1 complex contains 11 subunits: 3 respiratory subunits (MT-CYB, CYC1 and UQCRFS1), 2 core proteins (UQCRC1 and UQCRC2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of UQCRFS1). This cytochrome bc1 complex then forms a dimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-209Cytochrome b/b6 N-terminal region profile
Domain210-380Cytochrome b/b6 C-terminal region profile

Sequence similarities

Belongs to the cytochrome b family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    381
  • Mass (Da)
    43,120
  • Last updated
    2021-06-02 v1
  • Checksum
    26305B0C02E8A1B6
MTNIRKTHPLMKIINHSFIDLPAPSNISSWWNFGSLLGICLTVQIATGLFLAMHYTSDTMTAFSSVTHICRDVNYGWFIRYMHANGASMFFICLFLHVGRGVYYGSYTFMETWNIGVILLFTVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGSTLVEWIWGGFSVDKATLTRFFAFHFILPFIIAALAIVHLLFLHETGSNNPMGLNSDADKIPFHPYYTTKDILGILIMLTLLMTLVLFFPDLLGDPDNYMPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVVALILSILILAFLPLLHTSKQRSLMFRPITQTLYWMLVANLIILTWIGGQPVEHPFIIIGQLASISYFSIILILMPISGIIENKMLKWNL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MN807609
EMBL· GenBank· DDBJ
QOU10144.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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