A0A7R8Z8S5 · A0A7R8Z8S5_TIMDO

Function

function

Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular ComponentFACT complex
Molecular Functionnucleosome binding
Biological ProcessDNA repair
Biological ProcessDNA replication
Biological Processtranscription elongation by RNA polymerase II

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    FACT complex subunit

Gene names

    • ORF names
      TDIB3V08_LOCUS2582

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Polyneoptera > Phasmatodea > Timematodea > Timematoidea > Timematidae > Timema

Accessions

  • Primary accession
    A0A7R8Z8S5

Subcellular Location

Nucleus
Chromosome

Keywords

Interaction

Subunit

Component of the FACT complex.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain39-197FACT complex subunit Spt16 N-terminal lobe

Sequence similarities

Belongs to the peptidase M24 family. SPT16 subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    251
  • Mass (Da)
    28,072
  • Last updated
    2021-06-02 v1
  • Checksum
    3838A336A1187AC0
MQSSRGVGNHVYKSYEPCGVGAVFDWQLSCGLTYGYMKVDLEAFGAFHEKEAENSNEEGLTKVDAISAAVGVDEEVVYSKSTSLQTWLLGYELTDTIMLLTVDAIHFLASKKKIEFLRQIETNKDENDVPPVVLHVRDRNDDDKANFKALIDAIKGSKKGKTLGLFTKDNYPGQFMVAWRSALKKEEFENLDISAAIAYIMAPKEDSEILTTKKACLVSVDVFNKYLKDQIMEIIDSDKVGGFVQTVHTLY

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
OA565061
EMBL· GenBank· DDBJ
CAD7196229.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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