A0A7L4PIV2 · A0A7L4PIV2_9EURY
- ProteinThreonylcarbamoyl-AMP synthase
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids352 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t6A37) in tRNAs that read codons beginning with adenine.
Catalytic activity
- L-threonine + hydrogencarbonate + ATP = L-threonylcarbamoyladenylate + diphosphate + H2O
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 43 | L-threonine (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 66 | ATP (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 70 | ATP (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 75 | L-threonine (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 125 | ATP (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 129 | L-threonine (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 149 | L-threonine (UniProtKB | ChEBI) | ||||
Sequence: A | ||||||
Binding site | 151 | ATP (UniProtKB | ChEBI) | ||||
Sequence: S | ||||||
Binding site | 159 | ATP (UniProtKB | ChEBI) | ||||
Sequence: S | ||||||
Binding site | 189 | L-threonine (UniProtKB | ChEBI) | ||||
Sequence: S | ||||||
Binding site | 203 | ATP (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 241 | ATP (UniProtKB | ChEBI) | ||||
Sequence: Y |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | ATP binding | |
Molecular Function | double-stranded RNA binding | |
Molecular Function | L-threonylcarbamoyladenylate synthase | |
Molecular Function | tRNA binding | |
Biological Process | regulation of translational fidelity | |
Biological Process | tRNA processing |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameThreonylcarbamoyl-AMP synthase
- EC number
- Short namesTC-AMP synthase
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageArchaea > Euryarchaeota > Stenosarchaea group > Methanomicrobia > Methanocellales
Accessions
- Primary accessionA0A7L4PIV2
Proteomes
Subcellular Location
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 21-207 | YrdC-like | ||||
Sequence: KDKIRIAAEVIRNGGLVAFPTETVYGLGADAINPEAVASIFRAKNRPVDNPIIVHVADKEEVYKLTEDIPVMAEELMDFFWPGPLTLILKKSEIVPYVATGGLDTVAIRMPYHRISLDLISESGVPIAAPSANTAGKPSPTNAKHVIYDLGAKVDIVLDGGPTIIGVESTVLDMTYPTPKILRPGVI |
Sequence similarities
Belongs to the SUA5 family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length352
- Mass (Da)38,518
- Last updated2021-04-07 v1
- ChecksumD28C5752B9DB9F62