A0A7L2Z8H1 · A0A7L2Z8H1_JACJC

Function

function

Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates inositol hexakisphosphate (InsP6) at position 1 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates PP-InsP5 at position 1, produced by IP6Ks from InsP6, to produce (PP)2-InsP4. Activated when cells are exposed to hyperosmotic stress.
Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentplasma membrane
Molecular FunctionATP binding
Molecular Functiondiphosphoinositol-pentakisphosphate kinase activity
Molecular Functioninositol heptakisphosphate kinase activity
Molecular Functioninositol hexakisphosphate 1-kinase activity
Molecular Functioninositol hexakisphosphate 3-kinase activity
Molecular Functioninositol hexakisphosphate 5-kinase activity
Molecular Functioninositol-1,3,4,5,6-pentakisphosphate kinase activity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase
  • EC number

Gene names

    • Name
      Ppip5k1
    • ORF names
      JACJAC_R07821

Organism names

  • Taxonomic identifier
  • Strain
    • B10K-DU-002-59
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Charadriiformes > Jacanidae > Jacana

Accessions

  • Primary accession
    A0A7L2Z8H1

Proteomes

Subcellular Location

Cell membrane
Cytoplasm, cytosol
Membrane

Keywords

PTM/Processing

Keywords

Family & Domains

Features

Showing features for region, compositional bias, domain.

TypeIDPosition(s)Description
Region1-51Disordered
Compositional bias18-32Basic and acidic residues
Domain55-144VIP1 N-terminal
Region909-994Disordered
Compositional bias928-955Basic and acidic residues
Compositional bias956-994Polar residues
Region1151-1183Disordered

Sequence similarities

Belongs to the histidine acid phosphatase family. VIP1 subfamily.

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    1,203
  • Mass (Da)
    135,562
  • Last updated
    2021-04-07 v1
  • Checksum
    6AB8F0DBC7428CBE
MSSLTTPNEGENFAPRFVVGSRDDETDFLGSNMKTDEPDFFEDDEEEESPPERQIVVGICAMTKKSKSKPMTQILERLCKFEYITVVIMGEDVILNEPVENWPSCDCLISFHSKGFPLDKAVAYAKLCKPFLINDLDMQYYIQDRREVYRILQEEGIDLPRYAVLNRDPDRPEECNLVEGEDHVEVNGAVFPKPFVEKPVSAEDHNVYIYYPTSAGGGSQRLFRKIGSRSSVYSPESSVRKTGSYIYEEFMPTDGTDVKVYTVGPDYAHAEARKSPALDGKVERDSEGKEIRYPVMLTAMEKLVARKVCVAFKQTVCGFDLLRANGHSFVCDVNGFSFVKNSMKYYDDCAKILGNIIMRELAPQFHIPWSIPTEAEDIPIVPTTSGTMMELRCVIAVIRHGDRTPKQKMKMEVKHPRFFELFEKYDGYKTGKLKLKKPEQLQEVLDIARQLVVELGTHSDCEIEERKSKLEQLKSVLEMYGHFSGINRKVQLTYLPHGHPKAASEDEEARRESSPSLLLVLKWGGELTPAGRVQAEELGRAFRCMYPGGQGDYAGFPGCGLLRLHSTYRHDLKIYASDEGRVQMTAAAFAKGLLALEGELTPILVQMVKSANMNGLLDSDSDSLSSCQHRVKARLHEIMQKDAKFCEEDYEKLAPTGSASLLNSMTFIQNPVEVCNQVFTLIENLTSQIKKRLEDPKSADLQLYHSETLELMLQRWSKLERDFRMKNGRYDISKIPDIYDCIKYDVQHNCALKLEGTTELFKLSKALADVIIPQEYGINKEEKLEIAIGFCLPLIKKIQLDLQRTHEDESVNKLHPLYSRGVLSPGRHVRTRLYFTSESHVHSLLSIFRYGGLLDENKDEQWKRAMDYLSAISELNYMTQIVIMLYEDNNKDPSSEERFHVELHFSPGVKGCEEDRNAPTGFGFRPASAENEDKKADQGSLEDLSKEKNIDEPDRMQQRSPQPSEPVSLQRRSPLIRNRKTGSMEVLSESSSKSGGYRLFSTYSRQSSEMKQSGLGSQCTGLFSTTVLGGSSSAPNLQDYARSHGKKFASSLTYKDELLSMPAVKRFSVSFAKHPTNGFEGCSMVPTIYPLETLHNSLSLRQVNEFLTAVCRSCSESHVQSTAALFDSMIGSQIPGDPFMSQRILSSSSLPLRQRSDKPPWYSSGPSSTVSSAGPSSPTSVDNCTRFSFSEKLSVSPPKSEEQ

Features

Showing features for non-terminal residue, compositional bias.

TypeIDPosition(s)Description
Non-terminal residue1
Compositional bias18-32Basic and acidic residues
Compositional bias928-955Basic and acidic residues
Compositional bias956-994Polar residues
Non-terminal residue1203

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
VZTM01039734
EMBL· GenBank· DDBJ
NXT02685.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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