A0A7L2Z8H1 · A0A7L2Z8H1_JACJC
- ProteinInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase
- GenePpip5k1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1203 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates inositol hexakisphosphate (InsP6) at position 1 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates PP-InsP5 at position 1, produced by IP6Ks from InsP6, to produce (PP)2-InsP4. Activated when cells are exposed to hyperosmotic stress.
Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).
Catalytic activity
- 1D-myo-inositol hexakisphosphate + ATP = 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + ADPThis reaction proceeds in the forward direction.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | plasma membrane | |
Molecular Function | ATP binding | |
Molecular Function | diphosphoinositol-pentakisphosphate kinase activity | |
Molecular Function | inositol heptakisphosphate kinase activity | |
Molecular Function | inositol hexakisphosphate 1-kinase activity | |
Molecular Function | inositol hexakisphosphate 3-kinase activity | |
Molecular Function | inositol hexakisphosphate 5-kinase activity | |
Molecular Function | inositol-1,3,4,5,6-pentakisphosphate kinase activity |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Charadriiformes > Jacanidae > Jacana
Accessions
- Primary accessionA0A7L2Z8H1
Proteomes
Subcellular Location
PTM/Processing
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-51 | Disordered | ||||
Sequence: MSSLTTPNEGENFAPRFVVGSRDDETDFLGSNMKTDEPDFFEDDEEEESPP | ||||||
Compositional bias | 18-32 | Basic and acidic residues | ||||
Sequence: VVGSRDDETDFLGSN | ||||||
Domain | 55-144 | VIP1 N-terminal | ||||
Sequence: IVVGICAMTKKSKSKPMTQILERLCKFEYITVVIMGEDVILNEPVENWPSCDCLISFHSKGFPLDKAVAYAKLCKPFLINDLDMQYYIQD | ||||||
Region | 909-994 | Disordered | ||||
Sequence: VKGCEEDRNAPTGFGFRPASAENEDKKADQGSLEDLSKEKNIDEPDRMQQRSPQPSEPVSLQRRSPLIRNRKTGSMEVLSESSSKS | ||||||
Compositional bias | 928-955 | Basic and acidic residues | ||||
Sequence: SAENEDKKADQGSLEDLSKEKNIDEPDR | ||||||
Compositional bias | 956-994 | Polar residues | ||||
Sequence: MQQRSPQPSEPVSLQRRSPLIRNRKTGSMEVLSESSSKS | ||||||
Region | 1151-1183 | Disordered | ||||
Sequence: PLRQRSDKPPWYSSGPSSTVSSAGPSSPTSVDN |
Sequence similarities
Belongs to the histidine acid phosphatase family. VIP1 subfamily.
Family and domain databases
Sequence
- Sequence statusFragment
- Length1,203
- Mass (Da)135,562
- Last updated2021-04-07 v1
- Checksum6AB8F0DBC7428CBE
Features
Showing features for non-terminal residue, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: M | ||||||
Compositional bias | 18-32 | Basic and acidic residues | ||||
Sequence: VVGSRDDETDFLGSN | ||||||
Compositional bias | 928-955 | Basic and acidic residues | ||||
Sequence: SAENEDKKADQGSLEDLSKEKNIDEPDR | ||||||
Compositional bias | 956-994 | Polar residues | ||||
Sequence: MQQRSPQPSEPVSLQRRSPLIRNRKTGSMEVLSESSSKS | ||||||
Non-terminal residue | 1203 | |||||
Sequence: Q |
Keywords
- Technical term