A0A7L2Q5B4 · A0A7L2Q5B4_9PASS

  • Protein
    1-acylglycerol-3-phosphate O-acyltransferase ABHD5
  • Gene
    Abhd5
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Coenzyme A-dependent lysophosphatidic acid acyltransferase that catalyzes the transfer of an acyl group on a lysophosphatidic acid. Functions preferentially with 1-oleoyl-lysophosphatidic acid followed by 1-palmitoyl-lysophosphatidic acid, 1-stearoyl-lysophosphatidic acid and 1-arachidonoyl-lysophosphatidic acid as lipid acceptor. Functions preferentially with arachidonoyl-CoA followed by oleoyl-CoA as acyl group donors. Functions in phosphatidic acid biosynthesis. May regulate the cellular storage of triacylglycerol through activation of the phospholipase PNPLA2. Involved in keratinocyte differentiation. Regulates lipid droplet fusion.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-(9Z)-octadecenoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CoA
    This reaction proceeds in the forward direction.
  • 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + (9Z)-octadecenoyl-CoA = 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA
    This reaction proceeds in the forward direction.
  • 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + (9Z)-octadecenoyl-CoA = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA
    This reaction proceeds in the forward direction.
  • 1-hexadecanoyl-sn-glycero-3-phosphate + (9Z)-octadecenoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA
    This reaction proceeds in the forward direction.
  • 1-octadecanoyl-sn-glycero-3-phosphate + (9Z)-octadecenoyl-CoA = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA
    This reaction proceeds in the forward direction.
  • eicosanoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1-(9Z)-octadecenoyl-2-eicosanoyl-sn-glycero-3-phosphate + CoA
    This reaction proceeds in the forward direction.
  • 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + hexadecanoyl-CoA = 1-(9Z)-octadecenoyl-2-hexadecanoyl-sn-glycero-3-phosphate + CoA
    This reaction proceeds in the forward direction.
  • 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + octadecanoyl-CoA = 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phosphate + CoA
    This reaction proceeds in the forward direction.
  • a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA
    This reaction proceeds in the forward direction.
    EC:2.3.1.51 (UniProtKB | ENZYME | Rhea)

GO annotations

AspectTerm
Cellular Componentlipid droplet
Cellular Componentmitochondrion
Molecular Functioncarboxylic ester hydrolase activity
Molecular Functionlysophosphatidic acid acyltransferase activity
Biological Processlipid homeostasis
Biological Processnegative regulation of sequestering of triglyceride
Biological Processphosphatidic acid biosynthetic process
Biological Processpositive regulation of triglyceride catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    1-acylglycerol-3-phosphate O-acyltransferase ABHD5
  • EC number
  • Alternative names
    • Abhydrolase domain-containing protein 5

Gene names

    • Name
      Abhd5
    • ORF names
      HYPCIN_R02501

Organism names

  • Taxonomic identifier
  • Strain
    • B10K-DU-002-83
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Neoaves > Telluraves > Australaves > Passeriformes > Sylvioidea > Zosteropidae > Hypocryptadius

Accessions

  • Primary accession
    A0A7L2Q5B4

Proteomes

Subcellular Location

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain3-200AB hydrolase-1

Sequence similarities

Belongs to the peptidase S33 family. ABHD4/ABHD5 subfamily.

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    217
  • Mass (Da)
    24,443
  • Last updated
    2021-04-07 v1
  • Checksum
    9F9FC96BB6DC431D
ESIEEWRKEVGLEKMILLGHNLGGFLAAAYSLKYPSRVKHLILVEPWGFPERPDNAEHERPIPIWIKALGAILSPFNPLAGLRIAGPFGLSLVQRLRPDFKRKYSSMFDDNTVAEYIYHCNVQSPSGETAFKNMTIPYGWAKRPMLQRISQMDRDIPITVVYGARSCIDGNSGSTIQSLRPNSYVKTIAILGAGHYVYADQPEDFNEKVKDICDSVD

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue217

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
VYZP01049194
EMBL· GenBank· DDBJ
NXR92009.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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