A0A7L2PVC2 · A0A7L2PVC2_9PASS
- ProteinMacrophage-expressed gene 1 protein
- GeneMpeg1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids715 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Pore-forming protein involved in both innate and adaptive immunity. Plays a central role in antigen cross-presentation in dendritic cells by forming a pore in antigen-containing compartments, thereby promoting delivery of antigens for cross-presentation. Also involved in innate immune response following bacterial infection; shows antibacterial activity against a wide spectrum of Gram-positive, Gram-negative and acid-fast bacteria. Reduces the viability of the intracytosolic pathogen L.monocytogenes by inhibiting acidification of the phagocytic vacuole of host cells which restricts bacterial translocation from the vacuole to the cytosol. Required for the antibacterial activity of reactive oxygen species and nitric oxide.
Pore-forming protein that plays a central role in antigen cross-presentation in dendritic cells by mediating delivery of antigens for cross-presentation. Dendritic cells bridge innate and adaptive immunity by capturing exogenous antigens on MHC class-I molecules and presenting them to naive CD8+ T-cells. Acts by forming a pore in antigen-containing compartments, promoting the release of antigens into the cytosol, enabling generation of MHCI:peptide complexes and T-cell priming.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | phagocytic vesicle membrane | |
Biological Process | adaptive immune response | |
Biological Process | defense response to bacterium |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameMacrophage-expressed gene 1 protein
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Neoaves > Telluraves > Australaves > Passeriformes > Sylvioidea > Zosteropidae > Hypocryptadius
Accessions
- Primary accessionA0A7L2PVC2
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cytoplasmic vesicle, phagosome membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 653-674 | Helical | ||||
Sequence: VAGVTVAVLAGLATSLGMAWYG |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-21 | |||||
Sequence: MGWGLWGASLTWALLAWVTGA | ||||||
Chain | PRO_5029541539 | 22-715 | Macrophage-expressed gene 1 protein | |||
Sequence: EQPQELSSSSGVGVCSKTLKLSRLEVLPGGGWDNLRNLDMGRVINLGYSQCKTTEDGSYLIPDEIFTIPRKQSNLDINSEIIESWKDYQSITSASINLELSLFSSINGKFSSDFHRTKTHQVRDKAVTTRVQVRNLVYTAKIDPEAALDKAFKKQLLTIASHLENNQTQMADFLAEVLVLNYGTHAITSVDAGATLVQEDQIKATFLKDSWATRNTVTASAGVAFHSIVNVGTKESLDISSGFTKQYLDNRTNSRVESIGGTPFYPGITLKAWQERIHNQLVALDRSGLPLYYFIKPSALPELPVPTVRRVAQRVELAIRRYYTFNTALGCTDASSPNFNFHANTDDGSCEGTMANFTFGGVFQECVGLGGPDTDTLCRALEQRNPLTGAFSCPASYTPVLLGVQEREEGHSHLECHNKCTLGIFCHRKCQDVFWLSRVQFSTYWCAASGPVAPNSGYLFGGLFSTHGANPITGAQSCPSGYFPLKLFGELRVCVSQDYEAGAEYAVPFGGFFSCQTGNPLAGQHRGTAEDPHAKGCPPGFSQHLALISDSCQVQFCVQAGLLTGGSLPPARLPPFTRPPANLPAVDTLLVRDGDNTWVRDGQSHVWRLARPEEVQFAAEMVRGRGLSGGEVAGVTVAVLAGLATSLGMAWYGHRRYRARGYRALGAGDSPAPASPEHSTVLSMGEGYQQELEG |
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 32-347 | MACPF | ||||
Sequence: GVGVCSKTLKLSRLEVLPGGGWDNLRNLDMGRVINLGYSQCKTTEDGSYLIPDEIFTIPRKQSNLDINSEIIESWKDYQSITSASINLELSLFSSINGKFSSDFHRTKTHQVRDKAVTTRVQVRNLVYTAKIDPEAALDKAFKKQLLTIASHLENNQTQMADFLAEVLVLNYGTHAITSVDAGATLVQEDQIKATFLKDSWATRNTVTASAGVAFHSIVNVGTKESLDISSGFTKQYLDNRTNSRVESIGGTPFYPGITLKAWQERIHNQLVALDRSGLPLYYFIKPSALPELPVPTVRRVAQRVELAIRRYYTFN | ||||||
Region | 689-715 | Disordered | ||||
Sequence: GDSPAPASPEHSTVLSMGEGYQQELEG |
Sequence similarities
Belongs to the MPEG1 family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusFragment
- Length715
- Mass (Da)77,649
- Last updated2021-04-07 v1
- Checksum94DFEDC7FE905E60
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: M | ||||||
Non-terminal residue | 715 | |||||
Sequence: G |
Keywords
- Technical term