A0A7L0VR78 · A0A7L0VR78_9PASE

  • Protein
    Macrophage-expressed gene 1 protein
  • Gene
    Mpeg1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    2/5

Function

function

Pore-forming protein involved in both innate and adaptive immunity. Plays a central role in antigen cross-presentation in dendritic cells by forming a pore in antigen-containing compartments, thereby promoting delivery of antigens for cross-presentation. Also involved in innate immune response following bacterial infection; shows antibacterial activity against a wide spectrum of Gram-positive, Gram-negative and acid-fast bacteria. Reduces the viability of the intracytosolic pathogen L.monocytogenes by inhibiting acidification of the phagocytic vacuole of host cells which restricts bacterial translocation from the vacuole to the cytosol. Required for the antibacterial activity of reactive oxygen species and nitric oxide.
Pore-forming protein that plays a central role in antigen cross-presentation in dendritic cells by mediating delivery of antigens for cross-presentation. Dendritic cells bridge innate and adaptive immunity by capturing exogenous antigens on MHC class-I molecules and presenting them to naive CD8+ T-cells. Acts by forming a pore in antigen-containing compartments, promoting the release of antigens into the cytosol, enabling generation of MHCI:peptide complexes and T-cell priming.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentphagocytic vesicle membrane
Biological Processadaptive immune response
Biological Processdefense response to bacterium

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Macrophage-expressed gene 1 protein
  • Alternative names
    • Perforin-2

Gene names

    • Name
      Mpeg1
    • ORF names
      LEPASP_R09130

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • B10K-DU-001-35
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Neoaves > Telluraves > Australaves > Passeriformes > Passeroidea > Nectariniidae > Leptocoma

Accessions

  • Primary accession
    A0A7L0VR78

Proteomes

Subcellular Location

Cytoplasmic vesicle, phagosome membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane653-674Helical

Keywords

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-21
ChainPRO_502959262422-718Macrophage-expressed gene 1 protein

Keywords

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain32-347MACPF
Region689-718Disordered

Sequence similarities

Belongs to the MPEG1 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    718
  • Mass (Da)
    77,603
  • Last updated
    2021-04-07 v1
  • Checksum
    829AEF1661990A6B
MGWGLWGVLLTWALLAWVTGAEQSQELSSSSGFGVCSKTLKLSRLEVLPGGGWDNLRNLDMGRVINLGYSQCKTTEDGSYLIPDEIFTIPRKQSNLDINSEIIESWKDYQSITSASINLELSLFSSINGKFSSDFRRTKTHQVRDKAVTTRVQVRNLVYTAKIDPEAPLDKAFKKQLLTIASHLENNQTRMADFLAEVLVLNYGTHAITSVDAGATLVQEDQIKATFLRDSWATRNAVTASAGAAFHSIVNVGTEESLDVSSGFTKQYLDNRTSSRVESIGGTPFYPGITLKTWQERIQNQLVALDRSGLPLHYLVRPSAVPELPAPTVRRVARQVELAIRRYYTFNTAPGCTDASSPNFNFHANADDGSCEGTVANFTFGGVFQECVGLGGPDTGALCGALEQRNPLTGAFSCPATYTPVLLAVQEREEGHSHLECHNKCTLGIFCHRECQDVFWLSRVRFSAYWCAASGPAAPNSGYLFGGLFSTYSANPITGAPSCPSGYLPLKLFGELRVCASQDYEEGAGHAVPFGGFFSCQAGNPLAGQHRGTAEDPHAKGCPPGFSQHLALISDSCQVQFCIRAGLLTGGSLLPARLPPFTRPPANLPAVDTLLVRDGDSTWVRDGQSHVWRLARPEEVRHVAEMARGRGLSGGQVAGVTVAVLAGLATGLGTAWYGHRRYRAMGYRELGTGDSPAPASPEHSTVLSVGEGYQQEPEGTVP

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue718

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
VXAX01007535
EMBL· GenBank· DDBJ
NXL81621.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp