A0A7L0T412 · A0A7L0T412_PODPO

Function

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • (5S,12S)-dihydroxy-(6E,10E,12E,14Z)-eicosatetraenoate + NADP+ = 12-oxo-(5S)-hydroxy-(6E,8E,10E,14Z)-eicosatetraenoate + H+ + NADPH
    This reaction proceeds in the forward direction.
  • 13,14-dihydro-15-oxo-PGF2alpha + NADP+ = 15-oxoprostaglandin F2alpha + H+ + NADPH
    This reaction proceeds in the backward direction.
  • 13,14-dihydro-15-oxo-prostaglandin E1 + NADP+ = 15-oxoprostaglandin E1 + H+ + NADPH
    This reaction proceeds in the backward direction.
  • 13,14-dihydro-15-oxo-prostaglandin F1alpha + NADP+ = 15-oxoprostaglandin F1alpha + H+ + NADPH
    This reaction proceeds in the backward direction.
  • 20-hydroxy-leukotriene B4 + NADP+ = 12-oxo-20-hydroxy-leukotriene B4 + H+ + NADPH
    This reaction proceeds in the forward direction.
  • 4-hydroxynonanal + NADP+ = (E)-4-hydroxynon-2-enal + H+ + NADPH
    This reaction proceeds in the backward direction.
  • 6-trans-leukotriene B4 + NADP+ = 12-oxo-(5S)-hydroxy-(6E,8E,10E,14Z)-eicosatetraenoate + H+ + NADPH
    This reaction proceeds in the forward direction.
  • NADP+ + nonan-2-one = (3E)-nonen-2-one + H+ + NADPH
    This reaction proceeds in the backward direction.
  • NADP+ + octanal = (2E)-octenal + H+ + NADPH
    This reaction proceeds in the backward direction.
  • NADP+ + pentan-2-one = (E)-pent-3-en-2-one + H+ + NADPH
    This reaction proceeds in the backward direction.
  • an n-alkanal + NADP+ = an alk-2-enal + H+ + NADPH
    This reaction proceeds in the backward direction.
    EC:1.3.1.74 (UniProtKB | ENZYME | Rhea)
  • decanal + NADP+ = (2E)-decenal + H+ + NADPH
    This reaction proceeds in the backward direction.
  • dodecanal + NADP+ = (2E)-dodecenal + H+ + NADPH
    This reaction proceeds in the backward direction.
  • hexanal + NADP+ = (E)-hex-2-enal + H+ + NADPH
    This reaction proceeds in the backward direction.
  • leukotriene B4 + NADP+ = 12-oxo-leukotriene B4 + H+ + NADPH
    This reaction proceeds in the forward direction.

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Function13-prostaglandin reductase activity
Molecular Function15-oxoprostaglandin 13-oxidase activity
Molecular Function2-alkenal reductase [NAD(P)+] activity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Prostaglandin reductase 1
  • EC number
  • Alternative names
    • 15-oxoprostaglandin 13-reductase
    • Dithiolethione-inducible gene 1 protein
    • Leukotriene B4 12-hydroxydehydrogenase
    • NAD(P)H-dependent alkenal/one oxidoreductase

Gene names

    • Name
      Ptgr1
    • ORF names
      PODPOD_R07212

Organism names

  • Taxonomic identifier
  • Strain
    • B10K-DU-009-04
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Podicipediformes > Podicipedidae > Podilymbus

Accessions

  • Primary accession
    A0A7L0T412

Proteomes

Subcellular Location

PTM/Processing

Keywords

Interaction

Subunit

Monomer or homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain39-329Enoyl reductase (ER)

Sequence similarities

Belongs to the NADP-dependent oxidoreductase L4BD family.

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    331
  • Mass (Da)
    36,332
  • Last updated
    2021-04-07 v1
  • Checksum
    7DE76B5A70B34EDF
MVTAKVWVLKKHFEGFPKPSDFDMKKIELPNLKDGGNRLLLESVFLSVDPYMRPYSRRDMKEGDIMIGTQVARVVESKNPAFTVGAFVVARSGWRTHFISDGKGLQLLPSSWPESLPKSLALGTVGMPGLTAYFGLLEVCKMKPGETVLVNAAAGAVGSVVGQLAKIGGGKVVGCAGSDDKVAYLKKIGFDEAFNYKTVPSLDEALRKASPDGYDCFFDNVGGEFTSIAITQMKKYGRIAVCGAISQYNDSVPQKGHYVQVPMIFKELRMEGFIVTRWDNRREEGLKALLKWVMEGKIKCHEQVTEGFENMPTAFIGMLKGENLGKAIVKV

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue331

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
VXAO01000717
EMBL· GenBank· DDBJ
NXL49153.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp