A0A7L0JLR6 · A0A7L0JLR6_CHATO
- Protein2',3'-cyclic-nucleotide 3'-phosphodiesterase
- GeneCnp_0
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids421 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Catalyzes the formation of 2'-nucleotide products from 2',3'-cyclic substrates. May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin.
Catalytic activity
- a nucleoside 2',3'-cyclic phosphate + H2O = a nucleoside 2'-phosphate + H+
Features
Showing features for active site, binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 250 | Proton acceptor | ||||
Sequence: H | ||||||
Binding site | 252 | substrate | ||||
Sequence: T | ||||||
Active site | 329 | Proton donor | ||||
Sequence: H | ||||||
Binding site | 331 | substrate | ||||
Sequence: T |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | melanosome | |
Cellular Component | membrane | |
Molecular Function | 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity | |
Biological Process | cyclic nucleotide catabolic process |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name2',3'-cyclic-nucleotide 3'-phosphodiesterase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Galloanserae > Anseriformes > Anhimidae > Chauna
Accessions
- Primary accessionA0A7L0JLR6
Proteomes
Subcellular Location
PTM/Processing
Keywords
- PTM
Interaction
Subunit
Exists as monomers and homodimers.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 184-420 | Cyclic nucleotide phosphodiesterase catalytic | ||||
Sequence: LPMYFGWFLSKRSSEILRKAGQVFLDELGSFKAFKKESKYFASAIEDPKIKIDLTSYFVKRPPGVLHCTTKYTEFGKAAGAEEYAQQEAVKASYGKSFTLSISALFITTKTVGARVELNEQQLLLWPGDADKLLSTDNLPKGSRAHITLGCANGIEAVQTGLDLLEFVKLEKTGNKGDEVGEIGGGKLQYFDNGMWMLVLSKKIDVRAIFSGYYGKGKLVPTQSTNKRGSAFSSCTI |
Sequence similarities
Belongs to the 2H phosphoesterase superfamily. CNPase family.
Family and domain databases
Sequence
- Sequence statusFragment
- Length421
- Mass (Da)47,651
- Last updated2021-04-07 v1
- ChecksumDCF009F5998E1D42
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: N | ||||||
Non-terminal residue | 421 | |||||
Sequence: I |
Keywords
- Technical term