A0A7K6NKB6 · A0A7K6NKB6_PEDTO

Function

function

Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor. The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm. Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentperoxisomal membrane
Biological Processprotein import into peroxisome matrix, docking

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Peroxisomal membrane protein PEX14
  • Alternative names
    • Peroxin-14

Gene names

    • Name
      Pex14
    • ORF names
      PEDTOR_R01021

Organism names

  • Taxonomic identifier
  • Strain
    • B10K-DU-029-80
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Charadriiformes > Pedionomidae > Pedionomus

Accessions

  • Primary accession
    A0A7K6NKB6

Proteomes

Subcellular Location

Keywords

Family & Domains

Features

Showing features for domain, region, coiled coil, compositional bias.

TypeIDPosition(s)Description
Domain3-40Peroxisome membrane anchor protein Pex14p N-terminal
Region42-64Disordered
Coiled coil136-163
Region198-346Disordered
Compositional bias210-271Polar residues
Compositional bias276-292Basic and acidic residues
Compositional bias293-307Acidic residues
Compositional bias308-346Basic and acidic residues

Sequence similarities

Belongs to the peroxin-14 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    346
  • Mass (Da)
    38,409
  • Last updated
    2021-04-07 v1
  • Checksum
    B685641194B7114E
VVTAVKFLQNPRVRQSPPATKRAFLKKKGLTDEEIDLAFQQSGTSTDEPPSPGPSTQLVPTQPSQHVAYSPRGYRWRDCGALAVILAGIAFGFKKYLLPLIMGQKEDRKQLQRIESNISEMSGSVTQTVTQLQTTLAAVQELLIQQQQKIQELTQELAASKATTSTNWILESQNINELKSEIYSLKGLLLNRRQFPPSPSAPKIPSWQIPVKPSSPSNPVVANHNSSSDISPVSNESTTSSPVKENHSPEGSKVSCHLLSTEESNKTVIDVKSQVRMEVQGEEEKRETKRNEEEEEDDEDDDVSHVDEEECLGVQTEDRRGGDGQINEQVEKLRRPEGASNENEID

Features

Showing features for non-terminal residue, compositional bias.

TypeIDPosition(s)Description
Non-terminal residue1
Compositional bias210-271Polar residues
Compositional bias276-292Basic and acidic residues
Compositional bias293-307Acidic residues
Compositional bias308-346Basic and acidic residues
Non-terminal residue346

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
VZRU01011489
EMBL· GenBank· DDBJ
NWW49193.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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